Programmed cell death of stressed keratinocytes and its inhibition by vitamin D: the role of death and survival signaling pathways

Apoptosis : an International Journal on Programmed Cell Death
T Diker-CohenA Ravid

Abstract

The epidermis is confronted with multiple environmental and pathophysiological stresses. This study shows that TNFalpha, oxidative stress, hyperosmotic and heat shock induced both caspase-dependent and independent cell death in human HaCaT keratinocytes. The hormonal form of vitamin D, 1,25(OH)2D3, which is an autocrine hormone in the epidermis, protected the cells from all the examined stresses and pathways leading to cell death. We aimed to define the signaling pathways that determine the life-death balance of stressed keratinocytes and participate in their protection by 1,25(OH)2D3. As assessed by employing specific inhibitors, the survival pathways mediated by the EGF receptor, ERK, PI-3K or Src kinase, or basal transcriptional activity are important for unstressed cell survival. However, only the EGF receptor, PI-3K and the Src kinase pathways mediate the survival of stressed cells in a stimulus-specific manner. Inhibition of the p38 and/or the JNK death pathways reduced caspase activation induced by oxidative stress, hyperosmotic shock and TNFalpha. The protective effect of 1,25(OH)2D3 was not mediated by the examined survival pathways. 1,25(OH)2D3 inhibited the stress-induced activation of p38 and JNK. Since mimicking th...Continue Reading

References

Aug 1, 1991·The Journal of Investigative Dermatology·P MildeE W Rauterberg
Apr 11, 1997·The Journal of Biological Chemistry·R V TalanianW W Wong
Oct 9, 1998·The Journal of Investigative Dermatology·M B SchilliA Menrad
Nov 24, 1998·Biochemical Pharmacology·R Gniadecki
Jan 7, 2000·Experimental Cell Research·C L Abram, S A Courtneidge
Aug 3, 2001·Nature Reviews. Molecular Cell Biology·M Leist, M Jäättelä
Jul 13, 2002·Journal of Cellular Physiology·Hao ChengAngel Alonso
Jan 1, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Anning Lin
Jan 10, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Richard L EckertFrederic Bone
Jan 10, 2003·Journal of Cellular Biochemistry·D D BikleY Oda
May 23, 2003·Journal of Cellular Biochemistry·Anat GamadyAmiram Ravid
Jul 26, 2003·The Journal of Investigative Dermatology·Anna EttorreAnna Di Stefano
Aug 6, 2003·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Bodo Lehmann, Michael Meurer
Aug 26, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alfons Lawen
Oct 17, 2003·Genes & Development·Jerry M Adams
Nov 25, 2003·Oncogene·Alexei DegterevJunying Yuan
Feb 26, 2004·Cell·Eugene E Varfolomeev, Avi Ashkenazi
Mar 17, 2004·Cancer Treatment Reviews·Juan Angel Fresno VaraManuel González-Barón
Mar 23, 2004·Annals of the New York Academy of Sciences·Talia Diker-CohenAmiram Ravid
Apr 13, 2004·Oncogene·Richard A Lockshin, Zahra Zakeri
Apr 13, 2004·Oncogene·Teiji Wada, Josef M Penninger
Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Pamela Renate MollKlaus Richter
Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·D D BikleZ Xie
Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Gregory E WeitsmanRuth Koren

❮ Previous
Next ❯

Citations

Jan 22, 2013·International Journal of Molecular Sciences·Katie M DixonRebecca S Mason
Aug 19, 2015·Journal of Cellular Physiology·Amiram RavidRuth Koren
Nov 9, 2011·Journal of Photochemistry and Photobiology. B, Biology·Yung-Che ChenBin Li
Jul 2, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ana Diez-SampedroAlessia Fornoni
Dec 29, 2015·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Ayşe Diljin KeçeciSafa Kurnaz
Dec 5, 2009·Dental Clinics of North America·Alex J Moule, Christopher A Moule
Mar 3, 2009·Journal of Endodontics·Hamid Jafarzadeh, Paul A Rosenberg
Nov 26, 2008·Journal of Endodontics·Hamid JafarzadehJun-Ichiro Kinoshita
Jan 23, 2016·The Saudi Dental Journal·Sageena GeorgeAnoop Harris
Apr 26, 2008·Journal of Endodontics·Jose L IbarrolaThomas J Beeson
May 16, 2007·Medical Hypotheses·Mark F McCartyFrancisco Contreras
Apr 18, 2007·Journal of Endodontics·Yoshitsugu TerauchiHideaki Suda
Jun 25, 2009·International Endodontic Journal·J Jan, D Krizaj
Feb 21, 2009·International Endodontic Journal·S E A CamargoG Schmalz
Aug 23, 2008·The British Journal of Dermatology·M LangbergA Ravid
Jul 11, 2013·Clinical and Experimental Dermatology·T MoriueY Kubota
Nov 24, 2011·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Steven C KwanNestor Cohenca
Jul 9, 2010·International Endodontic Journal·H Jafarzadeh, P V Abbott
Sep 18, 2010·The British Journal of Dermatology·T ZeeliA Ravid
Jul 26, 2012·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·Arpana Arthi Devi, Paul V Abbott
Aug 24, 2010·International Endodontic Journal·H Jafarzadeh, P V Abbott
Jun 22, 2010·Journal of Cellular Biochemistry·Xinjian PengRajendra G Mehta
Dec 19, 2009·Journal of Cellular Physiology·K Bahar-ShanyR Koren
May 11, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·M H M El-KomyO G Shaker
Jul 20, 2010·International Endodontic Journal·I OrafiV E Rushton
Aug 30, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Keun Hyung BaeDong Sung Park
Feb 4, 2010·Acta Cirúrgica Brasileira·Alfredo GragnaniLydia Masako Ferreira
Oct 14, 2017·Nutrients·Alfredo Garcia LayanaJohanna M Seddon
Sep 26, 2015·The Cochrane Database of Systematic Reviews·Patrick Sequeira-ByronEman F Alrowaili
Dec 10, 2015·The Cochrane Database of Systematic Reviews·Massimo Del FabbroRoberto L Weinstein
Nov 3, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yoko YoshihisaTadamichi Shimizu

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
W A SpruillA L Kierszenbaum
The Journal of Steroid Biochemistry and Molecular Biology
Donald L TrumpCandace S Johnson
The Annals of Physiological Anthropology = Seiri Jinruigaku Kenkyūkai Kaishi
N IseE Miwa
© 2021 Meta ULC. All rights reserved