Programmed Death-Ligand 1 Expression in Muscle-Invasive Bladder Cancer Cystectomy Specimens and Lymph Node Metastasis: A Reliable Treatment Selection Biomarker?

Clinical Genitourinary Cancer
Deborah MukherjiAyman N Tawil

Abstract

The programmed death-1 (PD-1) pathway negatively regulates T-cell activation and has an important role in regulating antitumor host immunity. Monoclonal antibodies directed against PD-1 or the PD-1 ligand (PD-L1) have shown activity in several tumor types with preliminary data suggesting a relationship between PD-L1 expression and response. The aim of this study was to establish the frequency of PD-L1 expression in muscle-invasive bladder cancer and associated lymph node metastasis using immunohistochemistry and to investigate the feasibility of using PD-L1 expression as a biomarker to select patients for PD-1-directed therapy. Cases of radical cystectomy for muscle-invasive bladder cancer with no exposure to previous chemotherapy were identified and representative slides from archived paraffin-embedded blocks stained with anti-PD-L1 antibody (5H1 clone) were identified. PD-L1 positivity was defined by a 5% expression threshold. Fifty-two radical cystectomy specimens were reviewed. PD-L1 was overexpressed in the tumor cells of 5/52 (9.6%) of cystectomy specimens in this cohort with 17/52 (32.7%) of cases showing PD-L1 overexpression in tumor-infiltrating immune cells. Discordance was observed between PD-L1 expression in lymph n...Continue Reading

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Citations

Jul 13, 2016·British Journal of Cancer·Jung Ho KimGyeong Hoon Kang
Jan 24, 2017·Annales de pathologie·Virginie VerkarreYves Allory
Oct 30, 2016·The International Journal of Biological Markers·Jung-Soo PyoJung Yeon Kim
Feb 19, 2019·American Journal of Clinical Pathology·Aileen Grace P ArriolaPriti Lal
Jul 5, 2018·Journal for Immunotherapy of Cancer·Muhammad Umair MushtaqFotis Asimakopoulos
Jul 16, 2021·Urologic Oncology·Gerald Bastian SchulzJozefina Casuscelli
Sep 24, 2021·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J WhooleyW B Robb
Oct 26, 2021·Oncology Letters·Aikaterini Aravantinou-FatorouFlora Zagouri

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