Programmed Nanoparticle-Loaded Nanoparticles for Deep-Penetrating 3D Cancer Therapy

Advanced Materials
Jinhwan KimWon Jong Kim

Abstract

Tumors are 3D, composed of cellular agglomerations and blood vessels. Therapies involving nanoparticles utilize specific accumulations due to the leaky vascular structures. However, systemically injected nanoparticles are mostly uptaken by cells located on the surfaces of cancer tissues, lacking deep penetration into the core cancer regions. Herein, an unprecedented strategy, described as injecting "nanoparticle-loaded nanoparticles" to address the long-lasting problem is reported for effective surface-to-core drug delivery in entire 3D tumors. The "nanoparticle-loaded nanoparticle" is a silica nanoparticle (≈150 nm) with well-developed, interconnected channels (diameter of ≈30 nm), in which small gold nanoparticles (AuNPs) (≈15 nm) with programmable DNA are located. The nanoparticle (AuNPs)-loaded nanoparticles (silica): (1) can accumulate in tumors through leaky vascular structures by protecting the inner therapeutic AuNPs during blood circulation, and then (2) allow diffusion of the AuNPs for penetration into the entire surface-to-core tumor tissues, and finally (3) release a drug triggered by cancer-characteristic pH gradients. The hierarchical "nanoparticle-loaded nanoparticle" can be a rational design for cancer therapies...Continue Reading

References

Oct 7, 2004·Angewandte Chemie·Yi ChenChengde Mao
Mar 2, 2005·Nature Reviews. Cancer·Mauro Ferrari
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kwangjae ChoDong M Shin
Jun 3, 2008·Advanced Drug Delivery Reviews·Igor I SlowingVictor S-Y Lin
Jun 24, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Eun Seong LeeYou Han Bae
Jul 10, 2008·Molecular Pharmaceutics·Shyh-Dar Li, Leaf Huang
Sep 10, 2009·Angewandte Chemie·Enjun ChengDongsheng Liu
Sep 18, 2010·Chemical Communications : Chem Comm·Li LiDominik Eder
Apr 25, 2012·Annual Review of Biomedical Engineering·Alexandre AlbaneseWarren C W Chan
Oct 18, 2012·Chemical Society Reviews·Nicholas D Petkovich, Andreas Stein
Apr 11, 2014·Journal of the American Chemical Society·Andrea IdiliFrancesco Ricci
Oct 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Li TangJianjun Cheng
Oct 23, 2014·Journal of the American Chemical Society·Jongkook HwangJinwoo Lee
Nov 8, 2014·Advanced Materials·Weiwei GuoItamar Willner
Feb 7, 2015·Trends in Molecular Medicine·Xiaoyang XuOmid Farokhzad
May 15, 2015·ACS Applied Materials & Interfaces·Changshin JoJinwoo Lee
Sep 9, 2015·Nature Biotechnology·Elvin BlancoMauro Ferrari

❮ Previous
Next ❯

Citations

Jan 3, 2019·Angewandte Chemie·Manish DebnathJyotirmayee Dash
Jul 23, 2019·Advanced Materials·Bowen YangJianlin Shi
Dec 24, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chao YangHaitao Ran
Oct 17, 2019·Science Advances·Shuaidong HuoXing-Jie Liang
Jul 31, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yong WangJie He
Nov 27, 2019·Cancers·Lucia SalvioniDavide Prosperi
Oct 20, 2020·Advanced Healthcare Materials·Hyeongmok ParkWon Jong Kim
Dec 12, 2020·Advanced Science·Fay NicolsonSuchetan Pal
Feb 23, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chun WuYong-Qiang Li
Feb 20, 2021·Drug Design, Development and Therapy·Huajing YangWen Cheng
Aug 29, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Huang YangZhengwei Mao
Apr 27, 2021·Advanced Science·Xue-Liang LiuChao Fang
Jan 14, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qinyan SunShiguo Sun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved