Programmed necrosis in cardiomyocytes: mitochondria, death receptors and beyond

British Journal of Pharmacology
Junxia ZhangYan Zhang

Abstract

Excessive death of cardiac myocytes leads to many cardiac diseases, including myocardial infarction, arrhythmia, heart failure and sudden cardiac death. For the last several decades, most work on cell death has focused on apoptosis, which is generally considered as the only form of regulated cell death, whereas necrosis has been regarded to be an unregulated process. Recent findings reveal that necrosis also occurs in a regulated manner and that it is closely related to the physiology and pathophysiology of many organs, including the heart. The recognition of necrosis as a regulated process mandates a re-examination of cell death in the heart together with the mechanisms and therapy of cardiac diseases. In this study, we summarize the regulatory mechanisms of the programmed necrosis of cardiomyocytes, that is, the intrinsic (mitochondrial) and extrinsic (death receptor) pathways. Furthermore, the role of this programmed necrosis in various heart diseases is also delineated. Finally, we describe the currently known pharmacological inhibitors of several of the key regulatory molecules of regulated cell necrosis and the opportunities for their therapeutic use in cardiac disease. We intend to systemically summarize the recent progr...Continue Reading

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Citations

Dec 4, 2019·British Journal of Pharmacology·Xin WangMichelangelo Campanella
Sep 15, 2019·Journal of Muscle Research and Cell Motility·Ashraf KitmittoElizabeth J Cartwright
Mar 20, 2020·Oxidative Medicine and Cellular Longevity·Gengyuan CuiYang Guo
Nov 11, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yunxiang ZhouYongchuan Deng
Jan 29, 2021·Oxidative Medicine and Cellular Longevity·Hongyu ChenBin Zhao
Apr 23, 2021·Oxidative Medicine and Cellular Longevity·Zhuo ZhaoJichang Zhang
Jul 8, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yanyan QiSongtao An

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Methods Mentioned

BETA
dissection
deubiquitination
nuclear translocation
transgenic
electron microscopy

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