Nov 29, 2005

Programmed ribosomal frameshifting in HIV-1 and the SARS-CoV

Virus Research
I Brierley, Francisco J Dos Ramos

Abstract

Ribosomal frameshifting is a mechanism of gene expression used by several RNA viruses to express replicase enzymes. This article focuses on frameshifting in two human pathogens, the retrovirus human immunodeficiency virus type 1 (HIV-1) and the coronavirus responsible for severe acute respiratory syndrome (SARS). The nature of the frameshift signals of HIV-1 and the SARS-CoV will be described and the impact of this knowledge on models of frameshifting will be considered. The role of frameshifting in the replication cycle of the two pathogens and potential antiviral therapies targeting frameshifting will also be discussed.

Mentioned in this Paper

SARS2 gene
Severe Acute Respiratory Syndrome
Exploration With a Probe
RNA Conformation
Molecular Helix
Untranslated Regions
TRNA, peptidyl-
Genome
Enzymes, antithrombotic
Ferrets

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.