Programmed Switching of Single Polymer Conformation on DNA Origami

ACS Nano
Abhichart KrissanaprasitKurt Vesterager Gothelf

Abstract

DNA nanotechnology offers precise geometrical control of the positioning of materials, and it is increasingly also being used in the development of nanomechanical devices. Here we describe the development of a nanomechanical device that allows switching of the position of a single-molecule conjugated polymer. The polymer is functionalized with short single-stranded (ss) DNA strands that extend from the backbone of the polymer and serve as handles. The DNA polymer conjugate can be aligned on DNA origami in three well-defined geometries (straight line, left-turned, and right-turned pattern) by DNA hybridization directed by single-stranded guiding strands and ssDNA tracks extending from the origami surface and polymer handle. We demonstrate switching of a conjugated organic polymer conformation between left- and right-turned conformations of the polymer on DNA origami based on toehold-mediated strand displacement. The switching is observed by atomic force microscopy and by Förster resonance energy transfer between the polymer and two different organic dyes positioned in close proximity to the respective patterns. Using this method, the polymer conformation can be switched six times successively. This controlled nanomechanical swit...Continue Reading

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Citations

Jul 27, 2017·Nano Letters·Johanna ZessinMichael Mertig
Apr 27, 2018·Chemical Communications : Chem Comm·Daniel GudnasonVictoria Birkedal
Apr 12, 2019·Advanced Materials·Abhichart KrissanaprasitThomas H LaBean
Mar 9, 2020·Topics in Current Chemistry·Xuemei XuYuzhou Wu
Nov 3, 2016·Small·Min Kuang, Gengfeng Zheng
Oct 10, 2020·Advanced Materials·Chunzhi CuiDong June Ahn
Jul 11, 2020·Angewandte Chemie·Nadine HannewaldUlrich S Schubert
Nov 19, 2019·Biomacromolecules·Stefanie L BakerKrzysztof Matyjaszewski
Apr 18, 2020·Angewandte Chemie·Thorsten LückerathTanja Weil
Jan 15, 2021·Angewandte Chemie·Jurgen SchillLuc Brunsveld
Mar 20, 2021·Chemical Reviews·Colette J WhitfieldTanja Weil
May 4, 2021·ACS Nano·Mikael MadsenKurt V Gothelf
Jun 13, 2017·Chemical Reviews·Fan HongHao Yan
Feb 5, 2019·Chemical Reviews·Friedrich C SimmelHari R Singh
Feb 5, 2019·Chemical Reviews·Mikael Madsen, Kurt V Gothelf
Nov 30, 2018·ACS Applied Materials & Interfaces·Bo ZhangJerry Y Y Heng
Jun 10, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Zhen-Gang WangBaoquan Ding
Nov 9, 2018·Biomacromolecules·Thorsten LueckerathTanja Weil

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