Programmed translational bypassing elements in mitochondria: structure, mobility, and evolutionary origin

Trends in Genetics : TIG
Jozef NosekB F Lang

Abstract

Programmed translational bypassing enables ribosomes to 'ignore' a precise mRNA interval of several dozen nucleotides. Well-characterized bypassed sequences include hop and byp elements, present in bacteriophage T4 and mitochondria of the yeast Magnusiomyces capitatus, respectively. The bypassing mechanism of byps is probably similar to that of hop, yet the former appears more effective and less constrained as to sequence context. Furthermore, both elements are mobile but hop moves as part of a cassette including a homing endonuclease, whereas byps seem to spread like miniature DNA transposable elements known as GC clusters. Here, we argue that hop and byps arose independently by convergent evolution, and that byps evolved in magnusiomycete mitochondria due to (as yet unknown) alterations of the mitochondrial translation machinery.

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Citations

Jun 13, 2015·BMC Genomics·John F WoltersHeather L Fiumera
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Nov 7, 2019·Yeast·Bernard Dujon
Mar 12, 2020·Journal of Molecular Evolution·Ľubomír Tomáška, Jozef Nosek
Nov 21, 2018·Current Genetics·Bronislava BrejováJozef Nosek
Jun 22, 2021·Frontiers in Microbiology·Federica De LiseBeatrice Cobucci-Ponzano

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