Programmed ventricular stimulation after myocardial infarction does not help reduce the risk of ventricular events

Cardiovascular Drugs and Therapy
B Brembilla-PerrotD Beurrier

Abstract

Programmed ventricular stimulation could be a useful technique to detect patients at high risk for ventricular arrhythmias and sudden death after acute myocardial infarction. However, prevention of arrhythmic events using this technique has never been demonstrated. To determine whether prophylactic antiarrhythmic therapy influences prognosis after acute myocardial infarction, 196 patients without spontaneous ventricular tachycardia (VT) but with inducible sustained monomorphic VT were followed for 3 +/- 1 years. Ninety-seven patients were not treated (control group). In 99 patients (study group), the antiarrhythmic therapy was guided by electrophysiologic study: One to four trials using class I, II, and III antiarrhythmic drugs were performed until the VT was not inducible or the induced VT was slower and was associated with hemodynamic stability. An effective antiarrhythmic drug prevented VT induction in 34 patients (34%; group I). Sixty-five patients (group II) still had inducible VT with the antiarrhythmic drug. Group II differed from group I in having a higher incidence of an inferior myocardial infarction location (57% vs. 47%; NS), a lower left ventricular ejection fraction (36.5% vs. 41%; NS), a slower rate of induced VT...Continue Reading

References

Apr 1, 1992·Journal of the American College of Cardiology·H L GreeneR W Henthorn
Feb 1, 1992·Journal of the American College of Cardiology·R T HahnR B Devereux
Feb 1, 1992·American Heart Journal·H R MiddlekauffJ H Tillisch
Apr 1, 1991·American Heart Journal·B Brembilla-PerrotY Juillière
Aug 1, 1987·Journal of the American College of Cardiology·J B KostisC Furberg
Dec 1, 1989·JAMA : the Journal of the American Medical Association·L K HineT C Chalmers
Oct 19, 1988·The American Journal of Cardiology·D L KucharJ N Ruskin
Jul 1, 1987·Journal of the American College of Cardiology·A H KadishF E Marchlinski
Aug 1, 1987·British Heart Journal·B Brembilla-PerrotC Pernot
Aug 1, 1985·Journal of the American College of Cardiology·M H SchoenfeldJ N Ruskin
Sep 22, 1983·The American Journal of Cardiology·C D Furberg
Mar 24, 1995·International Journal of Cardiology·B Brembilla-PerrotN Danchin

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Citations

May 22, 2009·Annales de cardiologie et d'angéiologie·B Brembilla-PerrotS Magalhes

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