Programmed Ventricular Stimulation for Risk Stratification in the Brugada Syndrome: A Pooled Analysis

Circulation
Jakub SroubekSteven A Lubitz

Abstract

The role of programmed ventricular stimulation in identifying patients with Brugada syndrome at the highest risk for sudden death is uncertain. We performed a systematic review and pooled analysis of prospective, observational studies of patients with Brugada syndrome without a history of sudden cardiac arrest who underwent programmed ventricular stimulation. We estimated incidence rates and relative hazards of cardiac arrest or implantable cardioverter-defibrillator shock. We analyzed individual-level data from 8 studies comprising 1312 patients who experienced 65 cardiac events (median follow-up, 38.3 months). A total of 527 patients were induced into arrhythmias with up to triple extrastimuli. Induction was associated with cardiac events during follow-up (hazard ratio, 2.66; 95% confidence interval [CI], 1.44-4.92, P<0.001), with the greatest risk observed among those induced with single or double extrastimuli. Annual event rates varied substantially by syncope history, presence of spontaneous type 1 ECG pattern, and arrhythmia induction. The lowest risk occurred in individuals without syncope and with drug-induced type 1 patterns (0.23%, 95% CI, 0.05-0.68 for no induced arrhythmia with up to double extrastimuli; 0.45%, 95% ...Continue Reading

References

Jun 5, 2003·Journal of Cardiovascular Electrophysiology·Pedro BrugadaJosep Brugada
Oct 28, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Duk-Woo ParkYou-Ho Kim
Dec 18, 2003·Journal of Cardiovascular Electrophysiology·Mohamed Chahine
May 10, 2006·Journal of the American College of Cardiology·Jesus Castro HeviaYanela Fayad Rodríguez
Jul 14, 2006·Journal of Cardiovascular Electrophysiology·Anil K GehiDavendra Mehta
Aug 28, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Kimie OhkuboAtsushi Hirayama
Dec 6, 2007·The Canadian Journal of Cardiology·Jean ChampagneGilles E O'Hara
Feb 4, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Yukiko NakanoYasuki Kihara
Feb 6, 2010·Journal of Cardiovascular Electrophysiology·Anna KostopoulouDennis Cokkinos
Oct 16, 2010·Pacing and Clinical Electrophysiology : PACE·Sana OualiSamir Kammoun
Jul 19, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Josep BrugadaPedro Brugada
Jul 20, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Arthur A M Wilde, Sami Viskin
Sep 24, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hisaki MakimotoWataru Shimizu
Nov 30, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Yutaka TakeHiroshi Ito
Dec 24, 2011·Journal of the American College of Cardiology·Silvia G PrioriMario Colombo
Feb 16, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Alessandro ZorziDomenico Corrado
Apr 17, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Frédéric SacherMichel Haïssaguerre
Jul 19, 2012·International Journal of Cardiology·Andrea SarkozyPedro Brugada
Nov 8, 2012·The New England Journal of Medicine·Arthur J MossUNKNOWN MADIT-RIT Trial Investigators
Jan 1, 2013·Circulation. Arrhythmia and Electrophysiology·Louise R A Olde NordkampJoris R de Groot
Feb 26, 2013·The American Journal of Cardiology·Shinsuke MiyazakiYoshito Iesaka
Oct 15, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Louise R A Olde NordkampHanno L Tan

❮ Previous
Next ❯

Citations

May 21, 2016·Frontiers in Cardiovascular Medicine·Jean-Baptiste GourraudVincent Probst
Jul 18, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Charles AntzelevitchArthur A M Wilde
Oct 21, 2016·Journal of Arrhythmia·Charles AntzelevitchArthur A M Wilde
Aug 9, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Pieter G Postema, Arthur A M Wilde
Nov 5, 2016·Nature Reviews. Cardiology·Juan SieiraPedro Brugada
Aug 26, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Giulio ContePedro Brugada
Jan 11, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Antonio CurcioCiro Indolfi
Apr 6, 2017·European Heart Journal·Juan SieiraPedro Brugada
Mar 8, 2017·Current Opinion in Cardiology·Andrea MazzantiSilvia G Priori
Mar 3, 2018·International Journal of Molecular Sciences·Anna Garcia-Elias, Begoña Benito
May 15, 2018·Expert Review of Cardiovascular Therapy·Mariana Argenziano, Charles Antzelevitch
May 13, 2017·Journal of Atrial Fibrillation·Yoshifusa Aizawa
Dec 20, 2017·Journal of Arrhythmia·Yukiko Nakano, Shimizu Wataru
Oct 11, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Masahiko TakagiUNKNOWN Japan Idiopathic Ventricular Fibrillation Study (J-IVFS) Investigators
Jun 29, 2018·Pacing and Clinical Electrophysiology : PACE·Can HasdemirCharles Antzelevitch
Dec 21, 2018·Pacing and Clinical Electrophysiology : PACE·Kevin M W LeongAmanda M Varnava
Jan 27, 2018·Cardiovascular Drugs and Therapy·Diogo de Almeida FernandesGuilherme Mariano Pego
Jul 30, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Jakrin KewcharoenWasawat Vutthikraivit
Oct 17, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Pietro DeliseLeonardo Calo
Jun 3, 2016·Clinical Medicine : Journal of the Royal College of Physicians of London·Elijah Behr, Bode Ensam
Mar 29, 2019·Arrhythmia & Electrophysiology Review·Carlo Pappone, Vincenzo Santinelli
Sep 12, 2019·Panminerva Medica·Milan M MarinkovićTatjana S Potpara
Mar 29, 2019·Arrhythmia & Electrophysiology Review·Jorge RomeroLuigi Di Biase
Mar 5, 2020·Minerva pediatrica·Fabrizio DragoUNKNOWN Italian Association of Arrhythmology and Cardiac Pacing (AIAC) and the Italian Society of Pediatric Cardiology (SICP)
May 28, 2019·European Cardiology·Daniel García IglesiasDavid Calvo
Mar 14, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Saori AsadaHiroshi Ito
Nov 21, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Gretje RoterbergMartin Borggrefe
Jan 15, 2020·European Cardiology·Afik D Snir, Hariharan Raju
Jul 21, 2020·Acta Cardiologica·Haarika KorliparaSrinivas Pentyala
Jul 4, 2018·Arrhythmia & Electrophysiology Review·Shohreh HonarbakhshPier D Lambiase
Apr 22, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Charles AntzelevitchArthur A M Wilde
Oct 11, 2017·Pacing and Clinical Electrophysiology : PACE·Konstantinos P LetsasJoachim R Ehrlich
Jun 27, 2018·Der Internist·B StallmeyerE Schulze-Bahr
Dec 21, 2018·Journal of the American Heart Association·Satoshi NagaseKengo Kusano
Jul 18, 2020·Nature Reviews. Disease Primers·Peter J SchwartzArthur A M Wilde
Jun 17, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jens Cosedis NielsenChristophe Leclercq
Oct 31, 2017·World Journal of Cardiology·Pietro DeliseNadir Sitta
Aug 24, 2019·Clinical Cardiology·Ibrahim El-BattrawyIbrahim Akin
Oct 23, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Konstantinos P LetsasAntonios Sideris

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.