Programming cell fate on bio-functionalized silicon

Colloids and Surfaces. B, Biointerfaces
Priyatha PremnathKrishnan Venkatakrishnan

Abstract

Controlling the growth of cells on the surface of silicon without an additive layer or topographical modification is unexplored. This research article delineates the discovery of unique properties of a bio-functionalized silicon substrate, programmed to repel or control cells, generated by ultrafast femtosecond pulse interaction with silicon. Remarkably, bio-functionalization in any shape or size without change in topology or morphology is observed indicating only sub-surface phase transformations. Material characterization reveals the presence of a unique mixture of phases of SiO2 and Si. Consequently, these variations in phase alter the physicochemical characteristics on the surface of silicon resulting in its bio-functionalization. The culture of mouse embryonic fibroblasts shows unique adhesion characteristics on these bio-functionalized silicon surfaces that include cell controlling, cell trapping, and cell shaping. Furthermore, the directionality of fibroblasts is restrained parallel to bio-functionalized zones as evidenced by changes in cytoskeleton. The controlling of proliferation, migration and adhesion of cells is attributed to unique phase bio-functionalization. This method presents considerable promise in a myriad ...Continue Reading

Citations

Apr 2, 2016·ACS Applied Materials & Interfaces·Amirhossein TavangarKrishnan Venkatakrishnan
Aug 2, 2015·Experimental Cell Research·Priyatha PremnathKrishnan Venkatakrishnan

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