Programming colloidal bonding using DNA strand-displacement circuitry

Proceedings of the National Academy of Sciences of the United States of America
Xiang ZhouHaojun Liang

Abstract

As a strategy for regulating entropy, thermal annealing is a commonly adopted approach for controlling dynamic pathways in colloid assembly. By coupling DNA strand-displacement circuits with DNA-functionalized colloid assembly, we developed an enthalpy-mediated strategy for achieving the same goal while working at a constant temperature. Using this tractable approach allows colloidal bonding to be programmed for synchronization with colloid assembly, thereby realizing the optimal programmability of DNA-functionalized colloids. We applied this strategy to conditionally activate colloid assembly and dynamically switch colloid identities by reconfiguring DNA molecular architectures, thereby achieving orderly structural transformations; leveraging the advantage of room-temperature assembly, we used this method to prepare a lattice of temperature-sensitive proteins and gold nanoparticles. This approach bridges two subfields: dynamic DNA nanotechnology and DNA-functionalized colloid programming.

References

Aug 19, 2000·Nature·B YurkeJ L Neumann
Aug 7, 2007·Physical Review Letters·Caroline Desgranges, Jerome Delhommelle
Nov 17, 2007·Science·David Yu ZhangErik Winfree
Feb 1, 2008·Nature·Dmytro NykypanchukOleg Gang
Feb 1, 2008·Nature·Sung Yong ParkChad A Mirkin
Nov 13, 2008·Physical Review Letters·D C Rapaport
May 1, 2009·Nature Materials·Wenlong ChengDan Luo
Jun 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Robert J MacfarlaneChad A Mirkin
Jul 23, 2011·Nature Chemistry·Sungwook Woo, Paul W K Rothemund
Oct 15, 2011·Science·Robert J MacfarlaneChad A Mirkin
Oct 27, 2011·Physical Review Letters·Yugang ZhangOleg Gang
Dec 14, 2011·The Journal of Chemical Physics·James GrantStephen Whitelam
Jun 19, 2012·Journal of the American Chemical Society·Tingjie Song, Haojun Liang
May 9, 2013·ACS Nano·Stephanie VialOleg Gang
May 21, 2013·Nature Materials·Chuan ZhangChad A Mirkin
Jul 5, 2013·Journal of the American Chemical Society·Youngeun KimChad A Mirkin
Sep 26, 2013·Chemical Society Reviews·Yu WangZhong-Qun Tian
Oct 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Robert J MacfarlaneChad A Mirkin
Dec 11, 2014·Annual Review of Physical Chemistry·Stephen Whitelam, Robert L Jack
Feb 7, 2015·Science·W Benjamin Rogers, Vinothan N Manoharan
Feb 24, 2015·Science·Matthew R JonesChad A Mirkin
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey D BrodinChad A Mirkin
Oct 21, 2015·Journal of the American Chemical Society·Dongbao YaoHaojun Liang
Feb 26, 2016·Science·Youngeun KimChad A Mirkin
Feb 26, 2016·Science·Wenyan LiuOleg Gang
Apr 12, 2017·Proceedings of the National Academy of Sciences of the United States of America·Zorana Zeravcic, Michael P Brenner
Apr 11, 2018·ACS Central Science·Kurinji KrishnamoorthyMichael J Bedzyk
Jun 15, 2019·Accounts of Chemical Research·Janet R McMillanChad A Mirkin

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Citations

May 14, 2021·Physical Chemistry Chemical Physics : PCCP·Qiuyan YuMingqing Chen
Oct 21, 2020·ACS Nano·Shuo YangTom F A de Greef
Oct 12, 2021·Journal of the American Chemical Society·Ho Fung ChengChad A Mirkin

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