Programming of growth hormone secretion and bone mineral density in elderly men: a hypothesis

The Journal of Clinical Endocrinology and Metabolism
C FallC Cooper

Abstract

Epidemiological studies suggest that retarded growth in infancy is associated with low adult bone mass. The mechanism underlying this association is unknown, but the programming of GH secretion or sensitivity by environmental influences during early development may play a role. We examined this issue in a sample of 37 healthy men, aged 63-73 yr, whose weight gain in infancy had been recorded. Venous blood samples were obtained under standard conditions every 20 min over a 24-h period. Measurements were made of the GH secretory profile, insulin-like growth factor I (IGF-I), IGF-binding protein-1 and -3, and GH-binding protein. Bone mineral density was measured at the lumbar spine and femoral neck using dual energy x-ray absortiometry. There was a statistically significant association between peak GH concentration (r = 0.46; P < 0.01) and fasting IGF-I concentration (r = 0.46; P < 0.01) with femoral neck bone density. After allowing for the peak GH concentration, median GH was negatively (P < 0.05) associated with bone mineral density. Weight at 1 yr was not related to peak GH, but was strongly related to the median GH concentration (r = 0.42; P = 0.01). These observations are consistent with a dual effect of GH secretion on bone...Continue Reading

Citations

Mar 23, 2005·Archives of Disease in Childhood·J H DaviesJ W Gregory
Jul 10, 2010·International Journal of Environmental Research and Public Health·Laura R GoodfellowNicholas C Harvey
Apr 14, 2006·Journal of Endocrinological Investigation·M LeganA Kocijancic
Mar 19, 2013·The Journal of Endocrinology·M J DevlinM L Bouxsein
Dec 7, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Cyrus CooperMark Hanson
Nov 26, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S A LanhamR O C Oreffo
Jul 3, 2007·Hormones and Behavior·I R HaraldsenS Opjordsmoen
May 25, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Morten FrostKaare Christensen
Mar 17, 2015·Journal of Animal Science and Biotechnology·Anita M Oberbauer
Jul 4, 2012·Nutrition Reviews·Andrea N HackerJanet C King
Oct 31, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rikke Beck JensenAnders Juul
Sep 15, 2009·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Chengya LiangM Renee Prater
Jul 30, 2008·Journal of Animal Physiology and Animal Nutrition·H FetouiN Zeghal
Feb 19, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jonathan H Tobias, Cyrus Cooper
Jan 26, 2002·British Medical Bulletin·C D Byrne
Sep 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K GodfreyC Cooper

❮ Previous
Next ❯

Related Concepts

Related Feeds

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.