Progranulin aggravates pulmonary immunopathology during influenza virus infection

Thorax
Qin LuoJu Cao

Abstract

Progranulin (PGRN) exerts multiple functions in various inflammatory diseases. However, the role of PGRN in the pathogenesis of virus infection is unknown. Here, we demonstrated that PGRN production was up-regulated in clinical and experimental influenza, which contributed to the deleterious inflammatory response after influenza virus infection in mice. PGRN-deficient mice were protected from influenza virus-induced lung injury and mortality. Decreased mortality was associated with significantly reduced influx of neutrophils and monocytes/macrophages, release of cytokines and chemokines, and permeability of the alveolar-epithelial barrier without affecting viral clearance. Our findings suggest that PGRN exacerbates pulmonary immunopathology during influenza virus infection.

References

Jan 14, 2003·Nature Medicine·Zhiheng HeAndrew Bateman
Dec 17, 2009·The New England Journal of Medicine·Bin CaoUNKNOWN National Influenza A Pandemic (H1N1) 2009 Clinical Investigation Group of China
Oct 24, 2012·Journal of Leukocyte Biology·Jinlong JianChuanju Liu
Oct 25, 2012·Thorax·Jürgen Schwarze, Karen J Mackenzie
May 6, 2016·American Journal of Respiratory and Critical Care Medicine·Zhixin SongJu Cao
Jun 9, 2017·The Journal of Infectious Diseases·Shan ZouJu Cao

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Citations

Sep 15, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaofang WangXuemei Zhang
Jul 25, 2019·Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry·Chunxiao LiuHongyan Wang
Dec 24, 2019·International Immunopharmacology·Gang TianJinbo Liu
Sep 4, 2021·Intensive Care Medicine Experimental·Florian BrandesGustav Schelling

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