Progranulin and Amyloid-β Levels: Relationship to Neuropsychology in Frontotemporal and Alzheimer's Disease

Journal of Alzheimer's Disease : JAD
Peter KörtvélyessyDaniel M Bittner

Abstract

Analysis of cerebrospinal fluid (CSF) has improved over the last few years; thus specific markers for different diseases have emerged, e.g., amyloid-β (Aβ) for Alzheimer's disease (AD) and progranulin for frontotemporal dementia (FTD). Evaluation of correlation between biomarkers in CSF and cognitive performance in populations with AD and FTD. 27 patients with AD and 16 with FTD were included. CSF tau, P-tau(181P), Aβ₄₂, and progranulin (PGRN) were measured and a standardized neuropsychological test battery applied. Olfactory testing was additionally included where available. For all patients across both groups, an association between PGRN and categoric (p = 0.016) and letter fluency (p = 0.029), naming (p = 0.003), and overall cognition (Mini-Mental State Examination: p = 0.04) was observed. Aβ42 was strongly associated with memory function (learning: p = 0.001; recall: p = 0.002). A correlation between Aβ₄₂ and memory performance was moreover found for each group separately, while PGRN also showed a correlation with recognition memory (p = 0.04) in AD. Furthermore, an association between reduced PGRN and olfactory dysfunction was revealed (p = 0.01). CSF-levels of PGRN and Aβ₄₂ levels express deficits in cognition differentia...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jul 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rachael DanielAndrew Bateman
Oct 6, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·T HummelA Mackay-Sim
Oct 10, 2007·Archives of Neurology·Nathalie BrouwersKristel Sleegers
Jan 14, 2009·Archives of Neurology·Matteo PardiniJordan Grafman
Mar 20, 2009·Annals of Neurology·Leslie M ShawUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 22, 2010·The Journal of Reproduction and Development·Takashi MatsuwakiMasugi Nishihara
Sep 6, 2011·Journal of Alzheimer's Disease : JAD·Miryam CarecchioDaniela Galimberti
Aug 1, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Esther L G E KoedamYolande A L Pijnenburg
Nov 15, 2012·Journal of Autoimmunity·Lorenz ThurnerMichael Pfreundschuh
Sep 21, 2013·Journal of Cell Science·Eugenia PetoukhovShernaz X Bamji

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Citations

Apr 23, 2016·Journal of Alzheimer's Disease : JAD·Eline A J WillemseCharlotte E Teunissen
Sep 17, 2019·The Journal of International Medical Research·Tiziana CasoliGiuseppe Pelliccioni
Nov 22, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Shannon L RisacherAndrew J Saykin
Mar 2, 2017·International Journal of Molecular Sciences·Peter KörtvelyessyDaniel M Bittner
May 11, 2018·American Journal of Alzheimer's Disease and Other Dementias·Alessandro Tonacci, Lucia Billeci
Nov 30, 2018·EMBO Molecular Medicine·Marc Suárez-CalvetUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 4, 2020·Therapeutic Advances in Neurological Disorders·Marta Milà-AlomàJosé Luís Molinuevo
Apr 23, 2016·Journal of Alzheimer's Disease : JAD·Shan-Shan TangJin-Tai Yu
Oct 5, 2018·Frontiers in Neurology·Peter KörtvelyessyDaniel Bittner
Aug 18, 2018·The Biochemical Journal·Anthony J Hayes, James Melrose
Jun 6, 2019·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Márcia RadanovicOrestes V Forlenza
Feb 14, 2021·Brain Sciences·Donovan A McGrowderRuby Alexander-Lindo
Mar 14, 2021·Molecular Neurobiology·Peng-Fei ZhangJin-Tai Yu
May 1, 2021·Journal of Neurochemistry·Xiao-Ming WangQing Tian

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