Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis

Mediators of Inflammation
Lucie Andrés CerezoL Senolt

Abstract

Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to assess the relationship between PGRN and disease activity in RA. PGRN levels were evaluated in patients with RA (n = 47) and OA (n = 42) and healthy controls (n = 41). Immunohistochemical analysis of PGRN in synovial tissues was performed. The association between PGRN and C-reactive protein (CRP), disease activity score (DAS28-CRP), and health assessment questionnaire (HAQ) was studied. Circulating PGRN was elevated in patients with RA and OA compared to healthy controls (227.1 ± 100.2 and 221.5 ± 102.5 versus 128.1 ± 34.7 ng/mL; P < 0.001). Synovial fluid levels of PGRN were higher in patients with RA compared to OA (384.5 ± 275.3 versus 241.4 ± 165.2 ng/mL; P = 0.002). PGRN expression was significantly upregulated in the synovial tissue of RA patients particularly in the inflammatory infiltrates. Serum PGRN levels correlated with DAS28 (r = 0.327, P = 0.049) and HAQ score (r = 0.323, P = 0.032), while synovial fluid PGRN correlated only with HAQ (r = 0.310, P = 0.043) in patients with RA. PGRN levels were not associated with CRP or autoantibodies. This study demonstrates increased PGRN expression at local sites of i...Continue Reading

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Citations

Aug 10, 2016·Annals of the New York Academy of Sciences·Jianlu WeiChuanju Liu
Aug 17, 2016·Cytokine·Jinlong JianChuanju Liu
Oct 30, 2016·Expert Review of Clinical Immunology·Ladislav Šenolt
Feb 28, 2018·British Journal of Pharmacology·Vera FranciscoOreste Gualillo
Nov 30, 2018·Clinical and Experimental Pharmacology & Physiology·Andrzej KotelaIreneusz Kotela
Oct 8, 2020·International Journal of Rheumatic Diseases·Ender Özgün ÇakmakMehmet Engin Tezcan

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Methods Mentioned

BETA
ELISA

Software Mentioned

R
Statistical Analysis System ( SAS )

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