Progranulin levels in blood in Alzheimer's disease and mild cognitive impairment

Annals of Clinical and Translational Neurology
Yonatan A CooperGiovanni Coppola

Abstract

Changes in progranulin (GRN) expression have been hypothesized to alter risk for Alzheimer's disease (AD). We investigated the relationship between GRN expression in peripheral blood and clinical diagnosis of AD and mild cognitive impairment (MCI). Peripheral blood progranulin gene expression was measured, using microarrays from Alzheimer's (n = 186), MCI (n = 118), and control (n = 204) subjects from the University of California San Francisco Memory and Aging Center (UCSF-MAC) and two independent published series (AddNeuroMed and ADNI). GRN gene expression was correlated with clinical, demographic, and genetic data, including APOE haplotype and the GRN rs5848 single-nucleotide polymorphism. Finally, we assessed progranulin protein levels, using enzyme-linked immunosorbent assay, and methylation status using methylation microarrays. We observed an increase in blood progranulin gene expression and a decrease in GRN promoter methylation in males (P = 0.007). Progranulin expression was 13% higher in AD and MCI patients compared with controls in the UCSF-MAC cohort (F2,505 = 10.41, P = 3.72*10-5). This finding was replicated in the AddNeuroMed (F2,271 = 17.9, P = 4.83*10-8) but not the ADNI series. The rs5848 SNP (T-allele) predict...Continue Reading

References

Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Feb 13, 2004·Bioinformatics·Laurent GautierRafael A Irizarry
Apr 25, 2006·Biostatistics·W Evan JohnsonAriel Rabinovic
Jun 6, 2007·BMC Systems Biology·Jun Dong, Steve Horvath
Sep 18, 2007·Nature Genetics·Harald H H GöringJohn Blangero
Jan 8, 2008·Nucleic Acids Research·Simon M LinWarren A Kibbe
May 10, 2008·Bioinformatics·Pan DuSimon M Lin
Jun 14, 2008·Annals of Neurology·Giovanni CoppolaDaniel H Geschwind
Jun 27, 2009·The Journal of Pathology·Sandra PeresonSamir Kumar-Singh
Aug 20, 2009·Current Alzheimer Research·Shannon L RisacherUNKNOWN Alzheimer's Disease Neuroimaging Initiative (ADNI)
Sep 2, 2009·The Journal of Reproduction and Development·Masatoshi SuzukiMasugi Nishihara
Feb 10, 2010·Archives of Neurology·Chang-En YuVivianna M Van Deerlin
Apr 14, 2010·PloS One·Jingyu LiuVince D Calhoun
Nov 5, 2010·Journal of the Neurological Sciences·Ging-Yuek R HsiungIan R A Mackenzie
Jul 17, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Daniela GalimbertiElio Scarpini
Feb 12, 2013·Journal of Alzheimer's Disease : JAD·Paola PiscopoAnnamaria Confaloni
Mar 12, 2013·Nucleic Acids Research·Timothy J TricheKimberly D Siegmund
Apr 24, 2013·JAMA Neurology·David C PerryGil Rabinovici
May 30, 2013·Nature Genetics·UNKNOWN GTEx Consortium
Sep 5, 2013·Journal of Alzheimer's Disease : JAD·Guido GainottiCamillo Marra
Mar 4, 2014·Journal of Affective Disorders·Sarah Kittel-SchneiderAndreas Reif
Mar 8, 2014·Molecular Medicine Reports·Li LuoJie Xu
May 8, 2014·Trends in Neurosciences·Terri L Petkau, Blair R Leavitt
Sep 30, 2014·Nature Methods·Yassen AssenovChristoph Bock
Aug 28, 2015·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Caroline Van CauwenbergheKristel Sleegers
Apr 25, 2017·Nature Reviews. Neuroscience·Aimee W KaoEric J Huang
Jun 27, 2017·Drug Discovery Today·Vanessa AbellaOreste Gualillo

❮ Previous
Next ❯

Citations

Jul 23, 2019·Critical Reviews in Clinical Laboratory Sciences·Peter D Fransquet, Joanne Ryan
Jun 5, 2019·Current Neuropharmacology·Pablo L CardozoFabíola M Ribeiro
Feb 28, 2020·Scientific Reports·Taesic Lee, Hyunju Lee
Mar 14, 2021·Molecular Neurobiology·Peng-Fei ZhangJin-Tai Yu
May 1, 2021·Journal of Neurochemistry·Xiao-Ming WangQing Tian
Jul 27, 2021·Neuroscience and Biobehavioral Reviews·Ludmila KucikovaCraig W Ritchie

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE63060

Methods Mentioned

BETA
ELISA
genotyping
blood draws
glycosylation

Software Mentioned

sva
WGCNA
ComBat
affy
BioConductor
Illumina BeadStation
BeadStudio
RnBeads
SDS

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

© 2022 Meta ULC. All rights reserved