Progress and challenges of integrated drug efficacy surveillance for uncomplicated malaria in Thailand.

Malaria Journal
Prayuth SudathipJui A. Shah

Abstract

Integrated drug efficacy surveillance (iDES) was formally introduced nationally across Thailand in fiscal year 2018 (FY2018), building on a history of drug efficacy monitoring and interventions. According to the National Malaria Elimination Strategy for Thailand 2017-2026, diagnosis is microscopically confirmed, treatment is prescribed, and patients are followed up four times to ensure cure. Routine patient data were extracted from the malaria information system for FY2018-FY2020. Treatment failure of first-line therapy was defined as confirmed parasite reappearance within 42 days for Plasmodium falciparum and 28 days for Plasmodium vivax. The primary outcome was the crude drug efficacy rate, estimated using Kaplan-Meier methods, at day 42 for P. falciparum treated with dihydroartemisinin-piperaquine plus primaquine, and day 28 for P. vivax treated with chloroquine plus primaquine; day 60 and day 90 efficacy were secondary outcomes for P. vivax. The proportion of patients with outcomes recorded at day 42 for P. falciparum malaria and at day 28 for P. vivax malaria has been increasing, with FY2020 follow-up rates of 61.5% and 57.2%, respectively. For P. falciparum malaria, day 42 efficacy in FY2018 was 92.4% (n = 249), in FY2019...Continue Reading

References

Nov 2, 2016·The American Journal of Tropical Medicine and Hygiene·Piero L OlliaroChansuda Wongsrichanalai
Apr 21, 2018·International Journal for Parasitology. Drugs and Drug Resistance·Kritpaphat TantiamornkulUsa Lek-Uthai
Jun 12, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cindy S ChuNicholas J White
Apr 18, 2019·The American Journal of Tropical Medicine and Hygiene·Prayuth SudathipRichard Reithinger
Dec 19, 2019·Tropical Medicine and Infectious Disease·Prayuth SudathipSumetha Hengprasert

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Citations

Dec 5, 2021·Malaria Journal·Rungniran SugaramMallika Imwong

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Software Mentioned

Stata
GraphPad Prism
TES
iDES

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