Progress and Current Trends in the Synthesis of Novel Polymers with Enhanced Mucoadhesive Properties

Macromolecular Bioscience
Ruairí P Brannigan, Vitaliy V Khutoryanskiy

Abstract

Mucoadhesion is defined as the adherence of a synthetic or natural polymer to a mucosal membrane via physical or chemical interactions. Mucoadhesive materials are widely used to develop dosage forms for transmucosal drug delivery via ocular, nasal, esophageal, oral, vaginal, rectal, and intravesical routes of administration. This review will discuss some of the most prominent and recent synthetic methodologies employed to modify polymeric materials in order to enhance their mucoadhesive properties. This includes chemical conjugation of polymers with molecules bearing thiol-, catechol-, boronate-, acrylate-, methacrylate-, maleimide-, and N-hydroxy(sulfo)succinimide ester- groups.

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Citations

Feb 12, 2020·Macromolecular Bioscience·Essi Taipaleenmäki, Brigitte Städler
Aug 14, 2020·Pharmaceutics·Twana Mohammed M WaysVitaliy V Khutoryanskiy
Jan 18, 2021·Colloids and Surfaces. B, Biointerfaces·Sam R AspinallVitaliy V Khutoryanskiy
Jan 15, 2021·Advances in Colloid and Interface Science·Brunella GrassiriAndreas Bernkop-Schnürch
Jun 13, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Andjelka RačićDanina Krajišnik
Jul 19, 2021·International Journal of Biological Macromolecules·Iuliia PilipenkoTatiana Tennikova
Nov 10, 2020·Journal of the American Chemical Society·Ana M S CostaJoão F Mano
Aug 27, 2021·International Journal of Pharmaceutics·Amina Ahmady, Nor Hayati Abu Samah

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