Progress and prospects: foamy virus vectors enter a new age

Gene Therapy
O Erlwein, M O McClure

Abstract

Foamy viruses, distantly related to the major subfamily of Retroviruses, Orthoretroviruses that include oncoviruses (for example, murine leukemia virus (MLV)) and lentiviruses (human immunodeficiency virus (HIV)), are endemic in mammalian species, but not in human populations. Humans infected by accidental or occupational exposure remain well. The virus is not transmitted to others, nor is it associated with any disease. These features added to its broad host range, efficient transduction of progenitor cells and an integration profile less likely to induce insertional mutagenesis, make these viruses attractive as vectors. Long-term reversal of disease phenotype in dogs with the genetic defect, leukocyte adhesion deficiency, by foamy virus vector therapy strengthens the case for their clinical exploitation.

References

Sep 14, 2006·Blood·Hans-Peter KiemDavid W Russell
Jan 9, 2007·Transfusion·James I BrooksPaul A Sandstrom
May 29, 2007·PLoS Pathogens·Jacqueline Lehmann-CheAli Saïb
Jul 12, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Helen GharwanDavid W Russell
Oct 24, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jason A TaylorRobert E Richard
Dec 25, 2007·Nature Medicine·Thomas R BauerDennis D Hickstein
Jan 11, 2008·AIDS Research and Human Retroviruses·Roumiana S BonevaLouisa E Chapman
Jan 23, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Paul C HendrieDavid W Russell
Mar 13, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Daniela ZychlinskiChristopher Baum
Mar 28, 2008·Journal of Virology·Melvyn W YapJonathan P Stoye
May 30, 2008·Journal of Virology·Fabian H LeendertzSandra Junglen
Jul 5, 2008·Emerging Infectious Diseases·Gregory A EngelLisa Jones-Engel
Aug 6, 2008·Emerging Infectious Diseases·Lisa Jones-EngelMaxine L Linial
Aug 9, 2008·The Journal of Clinical Investigation·Salima Hacein-Bey-AbinaMarina Cavazzana-Calvo
Oct 24, 2008·Journal of Virology·Marieke BokhovenMary K Collins
Nov 28, 2008·Nucleic Acids Research·Eugene ValkovPeter Cherepanov
Dec 5, 2008·Gene Therapy·A V CaprarielloS M Selkirk
Dec 17, 2008·The Journal of Biological Chemistry·Mario PerkovicCarsten Münk
Jan 15, 2009·The Journal of General Virology·Tatiana WiktorowiczAxel Rethwilm
Jan 15, 2009·The Journal of General Virology·Vladimir A MorozovHeinz Ellerbrok
Feb 10, 2009·Human Gene Therapy·Grant D TrobridgeHans-Peter Kiem

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Citations

Feb 27, 2013·Immunologic Research·Michael MühleJoachim Denner
Nov 18, 2011·Journal of Virology·Réjane RuaOlivier Schwartz
Oct 17, 2012·Biotechnology Advances·Shuohao Huang, Masamichi Kamihira
Nov 19, 2011·Blood·Isabelle RivièreMichel Sadelain
Mar 14, 2017·Nature Reviews. Genetics·Tania SultanaPascale Lesage

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