Progress in anti-HIV structure-based drug design

Trends in Biotechnology
M J Gait, J Karn

Abstract

The course of drug development for the treatment of HIV-1 infection and AIDS is being revolutionized by high-resolution structures of essential viral proteins. We survey the impact on drug design of the recently elucidated structural knowledge of two essential enzymes, reverse transcriptase and protease, and three new targets, the viral integrase and the gene regulatory protein-RNA interactions, Tat-TAR and Rev-RRE.

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Citations

Nov 5, 2002·Bioorganic & Medicinal Chemistry·Hongbin Yuan, Abby L Parrill
Jun 23, 2012·Biochemistry·Nina Z Hausmann, Brent M Znosko
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·S M TestaD H Turner
Nov 3, 2015·Biochimica Et Biophysica Acta·Gopinatha Suresh Kumar, Anirban Basu
Apr 10, 2015·The American Journal of Bioethics : AJOB·Liza Dawson
Jan 6, 1999·Antiviral Chemistry & Chemotherapy·P S Jones
May 7, 2019·Journal of Biomolecular Structure & Dynamics·Anirban Basu, Gopinatha Suresh Kumar
May 18, 1999·Biochemical and Biophysical Research Communications·T PersichiniP Ascenzi
Jul 3, 2010·Bioorganic & Medicinal Chemistry Letters·Pawan GuptaInder Pal Singh

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