Progress in basic and clinical research on HIV resistance: report on the XVIII International HIV Drug Resistance Workshop

Antiviral Therapy
Mark MascoliniDouglas D Richman

Abstract

Over nearly two decades, the International HIV Drug Resistance Workshop has become the leading forum for new research on viral resistance to agents developed to treat infection with HIV. The XVIII workshop featured work on HIV type-1 (HIV-1) persistence, reservoirs and elimination strategies; resistance to HIV-1 entry inhibitors (including a comparison of genotyping versus phenotyping to determine HIV-1 coreceptor use before treatment with CCR5 antagonists); polymerase domain resistance to reverse transcriptase inhibitors (including hepatitis B virus and HIV-1 resistance to lamivudine, and emergence of the K65R mutation in HIV-1 subtypes B and C); connection and RNase H domain resistance to reverse transcriptase inhibitors (including the effect of mutations in those domains on response to efavirenz and etravirine); resistance to hepatitis C virus and HIV-1 protease inhibitors; resistance to the integrase inhibitor raltegravir; global resistance epidemiology (including models to predict response to second-line antiretrovirals in resource-poor settings); and the role of minority resistant variants (including the effect of such variants on prevention of mother-to-child transmission of HIV-1). This report summarizes data from the o...Continue Reading

Citations

May 11, 2010·Journal of Virological Methods·Michael R JordanJohn M Coffin
May 11, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Silvia BertagnolioLuis E Soto-Ramirez
Jan 15, 2013·Journal of the International Association of Providers of AIDS Care·Brianna L KirkMichael A Tolle
May 1, 2010·Viruses·Michael A LobritzEric J Arts
Jul 5, 2016·Expert Opinion on Drug Metabolism & Toxicology·Denise Kreutzwiser, Alice Tseng

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