Progress in designing nucleic acid structures and fine-tuning their interactions

Archives of Biochemistry and Biophysics
H H KlumpC Lin

Abstract

The prediction of the structure of biological macromolecules at the atomic level and the design of new meta-stable structures and secondary interactions are critical tests of our understanding of the structures and the inter-atomic forces that underlie molecular biology. The capacity to accurately predict and design new structures and interactions will allow us to create nucleic acid sequences that will fold in new and useful ways. Here, we present some results to demonstrate the progress we have made in designing and assembling new nucleic acid structures that will make an increasingly important contribution to biology and medicine. We call the reaction cycle that exemplifies our approach 'A handshake from a hairpin on the way to a double helix.'

References

Aug 19, 2000·Nature·B YurkeJ L Neumann
Nov 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·J VölkerK J Breslauer
Feb 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Patrizia Alberti, Jean-Louis Mergny
Aug 30, 2003·Organic & Biomolecular Chemistry·Thomas CarellJohannes Gierlich
Sep 2, 2004·Journal of the American Chemical Society·Jong-Shik Shin, Niles A Pierce
Jul 26, 2005·Nucleic Acids Research·Samir AmraneJean-Louis Mergny

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