Progress in extracellular vesicle biology and their application in cancer medicine.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
Akhil SrivastavaRajagopal Ramesh

Abstract

Under the broader category of extracellular vesicles (EVs), exosomes are now well recognized for their contribution and potential for biomedical research. During the last ten years, numerous technologies for purification and characterization of EVs have been developed. This enhanced knowledge has resulted in the development of novel applications of EVs. This review is an attempt to capture the exponential growth observed in EV science in the last decade and discuss the future potential to improve our understanding of EVs, develop technologies to overcome current limitations, and advance their utility for human benefit, especially in cancer medicine. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

References

Jun 1, 1974·Journal of the National Cancer Institute·E W Benz, H L Moses
Apr 1, 1969·The Journal of Cell Biology·H C Anderson
May 1, 1967·British Journal of Haematology·P Wolf
Jan 30, 2008·Current Protocols in Cell Biology·Clotilde ThéryAled Clayton
Oct 8, 2009·Proteomics·Suresh Mathivanan, Richard J Simpson
Jun 24, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Dongmei SunHuang-Ge Zhang
Jan 1, 2009·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·S Sharma
Jun 1, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Joshua L Hood, Samuel A Wickline
Oct 12, 2012·PloS One·Deyi XiaoKelly M McMasters
May 28, 2013·Cancer Metastasis Reviews·Asfar S AzmiFazlul H Sarkar
Jun 13, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A MarkouE Lianidou
Aug 16, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Riccardo CazzoliHarvey I Pass
Apr 9, 2014·Cell Research·Basant Kumar ThakurDavid Lyden
Apr 11, 2014·International Review of Psychiatry·Shai Libson, Marc Lippman
Aug 2, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Luisa PascucciAugusto Pessina
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Oct 23, 2014·Cellular and Molecular Life Sciences : CMLS·Lindsey T BrintonKimberly A Kelly
Jan 8, 2015·Frontiers in Oncology·Laura Jayne Vella
Feb 17, 2015·Proteomics. Clinical Applications·Stephanie Boukouris, Suresh Mathivanan
Mar 5, 2015·Journal of Extracellular Vesicles·Kristine R JakobsenMalene M Jørgensen
Apr 4, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Matthew J HaneyElena V Batrakova
May 20, 2015·Nature Cell Biology·Bruno Costa-SilvaDavid Lyden
Jul 19, 2015·Molecular Aspects of Medicine·Mukesh KumarTaofeek K Owonikoko
Jul 22, 2015·Oncotarget·Anders ØverbyeAlicia Llorente
Aug 5, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elena V Batrakova, Myung Soo Kim
Aug 21, 2015·Expert Review of Molecular Diagnostics·Theresa L Whiteside
Oct 6, 2015·Journal of Molecular Biology·Shivakumar KeerthikumarSuresh Mathivanan
Nov 3, 2015·Nature·Ayuko HoshinoDavid Lyden
Nov 26, 2015·Cancer Letters·Radha MunagalaRamesh C Gupta
Dec 10, 2015·Journal of Extracellular Vesicles·Zachary J SmithSebastian Wachsmann-Hogiu
Dec 25, 2015·Journal of Extracellular Vesicles·Romain LinaresAlain R Brisson
Feb 20, 2016·Expert Review of Molecular Diagnostics·Oscar A Tovar-CamargoAjay Goel
Feb 26, 2016·Scientific Reports·Yuko T SatoKazunari Akiyoshi
Mar 10, 2016·Bioscience·MikoŁaj P ZaborowskiCharles P Lai
Apr 2, 2016·The Journal of Clinical Investigation·Rong XuRichard J Simpson
Jul 12, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Che-Ming LiuShian-Ying Sung
Jul 22, 2016·Journal of Extracellular Vesicles·Arron Thind, Clive Wilson
Sep 10, 2016·Breast Cancer Research : BCR·Bethany N HannafonW Q Ding

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Citations

Aug 6, 2020·Pharmaceutics·Thao T D Tran, Phuong H L Tran
Aug 28, 2020·International Journal of Molecular Sciences·Simona VillataValentina Cauda
Aug 28, 2020·International Journal of Molecular Sciences·Haoyao SunWei-Qun Ding
Dec 2, 2020·Pharmaceutics·Laia Hernandez-OllerSimo Schwartz
Dec 19, 2020·Frontiers in Oncology·Kaixiang FengDetao Yin
Feb 16, 2021·The AAPS Journal·Akhil SrivastavaRajagopal Ramesh
Apr 3, 2021·Seminars in Cancer Biology·Akira Yokoi, Takahiro Ochiya
Apr 27, 2021·Environmental Science. Processes & Impacts·Hannah M McMillanChristine Ogilvie Hendren
Jun 30, 2021·Journal of Experimental & Clinical Cancer Research : CR·Pablo Hernández-CamareroMacarena Perán
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Željka Peršurić, Sandra Kraljević Pavelić
Aug 11, 2021·Advanced Drug Delivery Reviews·Rajeswari RaguramanRajagopal Ramesh
Aug 15, 2021·Biotechnology Advances·Saeedreza Zeibi Shirejini, Fatih Inci
Aug 7, 2021·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Zivile UseckaiteAndrew Rowland

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Methods Mentioned

BETA
biopsy
transfecting
fluorescence resonance
biopsies
density
size exclusion chromatography
pull down

Clinical Trials Mentioned

NCT03542253
NCT03821909
NCT01779583
NCT02702856
NCT02393703
NCT01159288
NCT01668849
NCT03974204
NCT01344109
NCT03738319

Software Mentioned

ExoQuick
ExoCarta
Exodisc

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