Progress in gap junction protein 43 in chronic pain

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Jing Liu, Dong Huang

Abstract

Gap junction (GJ) plays an important role in cell communication. It is widely distributed in mammalian organs and tissues (except red blood cells and skeletal muscle). The overexpression of GJ and the enhancement of function are closely related to the mechanism of peripheral and central pain sensitization. Astrocytes are the most abundant type of glial cell in the central nervous system, and the major structural components of gap junctions are the connexin 43 (Cx43) subunit. Cx43 may play key role in chronic pain process, including the regulation of the coupling and function of GJ.

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