Progress in Liver Transplant Tolerance and Tolerance-Inducing Cellular Therapies.

Frontiers in Immunology
Xiaoxiao DuZhonghua Klaus Chen

Abstract

Liver transplantation is currently the most effective method for treating end-stage liver disease. However, recipients still need long-term immunosuppressive drug treatment to control allogeneic immune rejection, which may cause various complications and affect the long-term survival of the recipient. Many liver transplant researchers constantly pursue the induction of immune tolerance in liver transplant recipients, immunosuppression withdrawal, and the maintenance of good and stable graft function. Although allogeneic liver transplantation is more tolerated than transplantation of other solid organs, and it shows a certain incidence of spontaneous tolerance, there is still great risk for general recipients. With the gradual progress in our understanding of immune regulatory mechanisms, a variety of immune regulatory cells have been discovered, and good results have been obtained in rodent and non-human primate transplant models. As immune cell therapies can induce long-term stable tolerance, they provide a good prospect for the induction of tolerance in clinical liver transplantation. At present, many transplant centers have carried out tolerance-inducing clinical trials in liver transplant recipients, and some have achieved ...Continue Reading

References

Mar 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A B LumsdenM H Kutner
Sep 1, 1996·Clinical and Experimental Immunology·R J Steptoe, A W Thomson
Feb 1, 1997·Transplantation Proceedings·G V MazariegosT E Starzl
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J DevlinR Williams
May 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M Sykes, D H Sachs
May 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R Y Calne
Jul 4, 2001·Nature Medicine·F O NestleD Hart
Jul 13, 2001·American Journal of Surgery·J M RabkinA J Olyaei
Aug 15, 2001·Transplantation·M TakatsukiK Tanaka
Aug 15, 2002·Transplantation Proceedings·Fumitaka OikeK Tanaka
Dec 10, 2002·Annual Review of Immunology·Ronald H Schwartz
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·George V MazariegosAngus W Thomson
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew L MellorDavid H Munn
Oct 4, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kyrsten D FairbanksPaul J Thuluvath
Jan 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Hélène PêcheMaria Cristina Cuturi
Jan 25, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Virginie FouquetOlivier Soubrane
Feb 15, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Panagiotis TryphonopoulosCamillo Ricordi
Apr 9, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Wei LiJames D Perkins
May 10, 2005·Transplantation·James D EasonGeorge E Loss
May 10, 2005·Arthritis and Rheumatism·Dominique FargeAntoine Toubert
May 28, 2005·Transplantation Proceedings·R GirlandaN D Heaton
Jun 7, 2005·Nature Medicine·Robert I LechlerLaurence A Turka
Apr 22, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Helen M EvansStefan Hübscher
Apr 28, 2006·The New England Journal of Medicine·Edward A Copelan
May 11, 2006·Blood·Sergio RutellaGiuseppe Leone
Aug 8, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J Lerut, A Sanchez-Fueyo
Sep 28, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Vincent DonckierMichel Goldman
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heth R TurnquistAngus W Thomson

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Citations

Jan 11, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Suk Kyun HongKyung-Suk Suh
Aug 11, 2021·European Journal of Immunology·Niloufar SafiniaGiovanna Lombardi

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Methods Mentioned

BETA
biopsies
biopsy
flow cytometry

Clinical Trials Mentioned

NCT02062944
NCT00647283
NCT00320606
NCT00135694
NCT02541916
NCT02549586
NCT02166177
NCT02618902
NCT02903537
NCT01352858

Software Mentioned

CliniMACS

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