Progress in locating the genetic causes of schizophrenia

Der Nervenarzt
Rainald MössnerDan Rujescu


Elucidation of the pathogenesis of schizophrenia is progressing rapidly. The importance of the glutamatergic system and the glutamate receptor GRM3 were shown in both genetic and pharmacological studies of the new drug LY2140023. The zinc finger domain-containing gene ZNF804A could be identified as a new schizophrenia susceptibility gene, while large copy number variants at 1q21.1 and 15q13.3 now are seen as monogenic causes of schizophrenia. It is anticipated that the coming years will see further rapid progress in the unraveling of the causes of schizophrenia.


Sep 6, 2011·European Archives of Psychiatry and Clinical Neuroscience·Rainald MössnerWolfgang Maier


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Related Concepts

Zinc Fingers
Pathogenic Aspects
Excitatory Amino Acid Receptor
LY 2140023
Cancer-Predisposing Gene
GRM3 gene
ZNF804A gene

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