Progress in locating the genetic causes of schizophrenia

Der Nervenarzt
Rainald MössnerDan Rujescu

Abstract

Elucidation of the pathogenesis of schizophrenia is progressing rapidly. The importance of the glutamatergic system and the glutamate receptor GRM3 were shown in both genetic and pharmacological studies of the new drug LY2140023. The zinc finger domain-containing gene ZNF804A could be identified as a new schizophrenia susceptibility gene, while large copy number variants at 1q21.1 and 15q13.3 now are seen as monogenic causes of schizophrenia. It is anticipated that the coming years will see further rapid progress in the unraveling of the causes of schizophrenia.

References

Sep 6, 2011·European Archives of Psychiatry and Clinical Neuroscience·Rainald MössnerWolfgang Maier

Citations

May 17, 2000·American Journal of Medical Genetics·A G Cardno, I I Gottesman
Oct 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ilya ChumakovJohn Realson
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael F EganDaniel R Weinberger
Nov 24, 2006·Nature·Richard RedonMatthew E Hurles
Sep 11, 2007·Nature Medicine·Daniel R Weinberger
Nov 14, 2007·American Journal of Human Genetics·Rainald MoessnerStephen W Scherer
Apr 19, 2008·Biological Psychiatry·Boris B QuednowMichael Wagner
Jul 11, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Rainald MössnerWolfgang Maier
Aug 1, 2008·Nature·Hreinn StefanssonKari Stefansson
Aug 5, 2008·Nature Genetics·Michael C O'DonovanMolecular Genetics of Schizophrenia Collaboration
Dec 5, 2008·European Archives of Psychiatry and Clinical Neuroscience·Wolfgang MaierRené Hurlemann

Related Concepts

Zinc Fingers
Pathogenic Aspects
Excitatory Amino Acid Receptor
LY 2140023
Pathogenesis
Cancer-Predisposing Gene
Schizophrenia
Brain
GRM3 gene
ZNF804A gene

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