Progress in reducing the burden of stroke

Clinical and Experimental Pharmacology & Physiology
J Chalmers, N Chapman

Abstract

1. The burden of stroke worldwide is growing rapidly, driven by an ageing population and by the rapid rate of urbanization and industrialization in the developing world. There are approximately 5 million fatal and 15 million non-fatal strokes each year and over 50 million survivors of stroke alive, worldwide, today. 2. The most important determinant of stroke risk is blood pressure, with a strong, continuous relationship between the level of the systolic and diastolic pressures and the risk of initial and recurrent stroke, in both Western and Asian populations. 3. Randomized clinical trials have clearly demonstrated that blood pressure lowering reduces the risk of initial stroke by 35-40% in hypertensive patients; but, until recently, there was no conclusive evidence that blood pressure lowering was effective in the secondary prevention of stroke. 4. The Perindopril Protection Against Recurrent Stroke Study (PROGRESS) has provided definitive evidence that blood pressure lowering in patients with previous stroke or transient ischaemic attack (TIA) reduces the incidence of secondary stroke by 28%, of major vascular events by 26% and of major coronary events by 26%. These reductions were all magnified by approximately 50% in a sub...Continue Reading

References

Mar 7, 1970·Lancet·A B Carter
Jul 22, 1974·JAMA : the Journal of the American Medical Association
Sep 1, 1996·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·UNKNOWN PROGRESS Management Committee
Jan 14, 1999·Journal of Hypertension·J Chalmers
Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsG Dagenais
Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·C SartiJ Tuomilehto
Dec 4, 2001·Bulletin of the World Health Organization·C D MathersS J Begg

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Citations

May 6, 2006·International Journal of Technology Assessment in Health Care·Devidas Menon, Tania Stafinski
Jun 13, 2003·Journal of the American Geriatrics Society·Gustavo C Román
Mar 31, 2009·European Journal of Internal Medicine·B SolunD Dicker
Dec 1, 2004·Stroke; a Journal of Cerebral Circulation·J K McGillI M Macrae

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