Progress in SIFT-MS: breath analysis and other applications

Mass Spectrometry Reviews
Patrik Spaněl, David Smith

Abstract

The development of selected ion flow tube mass spectrometry, SIFT-MS, is described from its inception as the modified very large SIFT instruments used to demonstrate the feasibility of SIFT-MS as an analytical technique, towards the smaller but bulky transportable instruments and finally to the current smallest Profile 3 instruments that have been located in various places, including hospitals and schools to obtain on-line breath analyses. The essential physics and engineering principles are discussed, which must be appreciated to design and construct a SIFT-MS instrument. The versatility and sensitivity of the Profile 3 instrument is illustrated by typical mass spectra obtained using the three precursor ions H(3)O(+), NO(+) and O(2)(+)·, and the need to account for differential ionic diffusion and mass discrimination in the analytical algorithms is emphasized to obtain accurate trace gas analyses. The performance of the Profile 3 instrument is illustrated by the results of several pilot studies, including (i) on-line real time quantification of several breath metabolites for cohorts of healthy adults and children, which have provided representative concentration/population distributions, and the comparative analyses of breath ...Continue Reading

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Citations

Apr 8, 2011·Journal of the American Society for Mass Spectrometry·Patrik ŠpanělDavid Smith
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Aug 19, 2014·The Journal of Thoracic and Cardiovascular Surgery·Michael BousamraXiao-An Fu
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