Progress in studies of epidermal stem cells and their application in skin tissue engineering.

Stem Cell Research & Therapy
Ronghua YangKun Xiong

Abstract

The epidermis, which is the outermost layer of mammalian skin, provides an essential barrier that is essential for maintenance of life. The epidermis is a stratified epithelium, which is maintained by the proliferation of epidermal stem cells (EPSCs) at the basal layer of the epidermis. As a unique cell population characterized by self-renewal and differentiation capabilities, EPSCs ensure the maintenance of adult skin homeostasis and participate in repair of the epidermis after injury. Recently, the utilization of EPSCs for wound healing and tissue regeneration has been attracting increased attention from researchers. In addition, the advances in tissue engineering have increased the interest in applying EPSCs in tissue-engineered scaffolds to further reconstitute injured tissues. In this review, we introduce research developments related to EPSCs, including methods recently used in the culture and enrichment of EPSCs, as well as advanced tools to study EPSCs. The function and mechanism of the EPSC-dermal units in the development and homeostasis of the skin are also summarized. Finally, the potential applications of EPSCs in skin tissue engineering are discussed.

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Citations

Dec 1, 2020·PloS One·Marius GenslerJan Hansmann
Jun 24, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Afra I TomaSteven L Goudy
Jun 18, 2021·World Journal of Stem Cells·Xi-Min HuKun Xiong

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Methods Mentioned

BETA
fluorescence-activated cell sorting
by flow cytometry
transgenic
bioprinting
rheology

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