PMID: 8962640Mar 1, 1996Paper

Progress in the development of human chorionic gonadotropin antifertility vaccines

American Journal of Reproductive Immunology : AJRI
V C Stevens

Abstract

Prototype human chorionic gonadotropin (hCG) vaccines have demonstrated the feasibility of effectively eliciting antibodies in women and inhibiting fertility in both humans and nonhuman primates. Also, no serious side-effects due to immunization against self antigens have been revealed to date. However, the formulations so far tested in clinical trials are not suitable for widespread applications due to problems associated with complexities in production, burdensome application procedures, the need for frequent booster immunizations or cost of manufacture. Current research efforts involve the development of delivery systems to permit annual or biannual intervals between immunizations for protection from pregnancy, procedures for mucosal immunizations, methods to reduce hypersensitivity and local reactions, and procedures for reducing the cost of production. Recent progress in understanding the crystalline structure of the hCG molecule has stimulated further studies to define immunological epitope sequences that might constitute immunogens in future vaccines. The incorporation of vaccine components into biodegradable microspheres has resulted in formulations that elicit elevated antibody levels in rabbits for more than one year....Continue Reading

References

Jan 1, 1992·International Journal of Clinical & Laboratory Research·J EnnenR Kurth
Jan 1, 1992·Scandinavian Journal of Immunology. Supplement·V C Stevens
Jun 1, 1985·American Journal of Reproductive Immunology and Microbiology : AJRIM·P H EhrlichR E Canfield
Aug 1, 1982·Journal of Reproductive Immunology·T FuchsJ Brundin
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M G Goodman, W O Weigle
May 1, 1993·The Journal of Clinical Endocrinology and Metabolism·A MilwidskyM Mayer
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·G P TalwarK Buckshee
Jun 9, 1994·Nature·A J LapthornN W Isaacs
Apr 1, 1993·American Journal of Reproductive Immunology : AJRI·V C Stevens

❮ Previous
Next ❯

Citations

Feb 1, 1997·American Journal of Reproductive Immunology : AJRI·C B Coulam
Nov 24, 2006·The Spanish Journal of Psychology·Igor P AshmarinElena V Shmalgausen
Jan 16, 2015·Advanced Biomedical Research·Seema LekhwaniRagini Singh
Sep 13, 2002·Expert Opinion on Investigational Drugs·Peter J Delves
Jul 24, 2007·Journal of Reproductive Immunology·Barbara E KurthJohn C Herr
Dec 1, 2009·Reproductive Medicine and Biology·Satish K Gupta, Pankaj Bansal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.