Progress in the pathogenesis and treatment of cardiac manifestations of neonatal lupus

Current Opinion in Rheumatology
Peter M IzmirlyJ P Buyon

Abstract

To provide new insights into pathogenesis, prevention and management of cardiac manifestations of neonatal lupus (cardiac neonatal lupus) and issues pertinent to all anti-SSA/Ro positive individuals of childbearing age. Antibody specificity with high risk for cardiac neonatal lupus remains elusive, but high titers of Ro60, Ro52 or Ro52p200 antibodies appear to be required. Varying antibody specificities to the p200 region of Ro52 can induce first-degree block in a rodent model. In consideration of the contribution of macrophages to inflammation and fibrosis in cardiac neonatal lupus, hydroxychloroquine (HCQ) is being considered as preventive therapy. Cord blood biomarkers support the association of fetal reactive inflammatory and fibrotic components with the development and morbidity of cardiac neonatal lupus. Data from U.S. and French registries do not provide evidence that the prompt use of fluorinated steroids in cases of isolated block significantly alters fetal/neonatal morbidity or mortality. The search for a high-risk cardiac neonatal lupus antibody profile remains, but high-titer antibodies to Ro60 and R052 are a consistent finding, and this may guide the need for fetal echocardiographic surveillance. The uniform use of...Continue Reading

References

Jul 28, 1983·The New England Journal of Medicine·J S ScottR P Skinner
Jul 13, 2002·Arthritis and Rheumatism·Stina SalomonssonMarie Wahren-Herlenius
Sep 16, 2003·Annals of the Rheumatic Diseases·N Costedoat-ChalumeauJ-C Piette
Sep 3, 2004·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J M P J BreurE J Meijboom
Apr 3, 2008·Arthritis and Rheumatism·Joanne H ReedTom P Gordon
Aug 30, 2008·Clinical and Experimental Immunology·L StrandbergM Wahren-Herlenius
Jan 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robert M ClancyJill P Buyon
Aug 11, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Linn S StrandbergMarie Wahren-Herlenius
Oct 12, 2011·Circulation·Håkan EliassonUNKNOWN Fetal Working Group of the European Association of Pediatric Cardiology
Aug 19, 2015·Autoimmunity Reviews·Kateri LevesqueUNKNOWN Group of collaborators
Sep 29, 2015·Acta Obstetricia Et Gynecologica Scandinavica·Amanda SkogSven-Erik Sonesson
May 10, 2016·Lupus Science & Medicine·Peter M Izmirly, Amit Saxena

❮ Previous
Next ❯

Citations

Feb 21, 2018·Biomarkers in Medicine·Chiara BaldiniStefano Bombardieri
Nov 9, 2017·Clinical Reviews in Allergy & Immunology·Federica VanoniGregorio P Milani
Apr 14, 2020·Prenatal Diagnosis·Meghana A LimayeShilpi S Mehta-Lee
Aug 14, 2020·Curēus·Vivian VegaSabita Bhatta
Jun 27, 2020·The Journal of International Medical Research·Min HouYi-Hua He
May 24, 2019·Frontiers in Cardiovascular Medicine·Yongxia Sarah QuMohamed Boutjdir
Jan 21, 2021·Journal of Perinatal Medicine·Julia Marta DerdulskaAleksandra Wilkowska
Jan 9, 2021·Frontiers in Pediatrics·Sara De CarolisSilvia Salvi
Feb 9, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Roberta MilazzoIrene Cetin
May 29, 2021·Neurology. Neuroimmunology and Neuroinflammation·Ester CoutinhoAngela Vincent
Jul 4, 2021·Rheumatic Diseases Clinics of North America·Amanda Moyer, Eliza F Chakravarty
Apr 3, 2021·The Journal of Rheumatology·Talia DiazLinda T Hiraki
Sep 28, 2021·Journal of Cardiovascular Electrophysiology·Giacomo M CioffiGiovanni Battista Forleo
Dec 12, 2017·Best Practice & Research. Clinical Rheumatology·Rebecca Fischer-Betz, Christof Specker
Jan 4, 2022·Lupus·Sanitra AnuwutnavinNalat Sompagdee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.