Progress in the pharmacotherapy of gout

Current Opinion in Rheumatology
John S Sundy

Abstract

To summarize new knowledge on approved and emerging drugs used to treat hyperuricemia or the clinical manifestations of gout. Results of several clinical trials provide new data on the efficacy and safety of the approved urate-lowering drugs, allopurinol and febuxostat. New recommendations have been presented on appropriate dosing of colchicine for acute gout flares and potential toxicities of combining colchicine with medications such as clarithromycin. Emerging therapies, including pegloticase, the uricosuric agent RDEA596, and the interleukin-1 inhibitors, rilonacept and canakinumab, have shown promise in early and late phase clinical trials. Recent publications demonstrate an opportunity to use existing gout therapies more effectively in order to improve both efficacy and safety. Emerging therapies for gout show promise for unmet needs in selected gout populations.

References

Sep 5, 2002·Arthritis and Rheumatism·Fernando Perez-RuizAna Ruibal
Mar 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shuen-Iu HungYuan-Tsong Chen
Dec 13, 2005·The New England Journal of Medicine·Michael A BeckerNancy Joseph-Ridge
Jan 13, 2006·Nature·Fabio MartinonJürg Tschopp
Jul 14, 2006·Mayo Clinic Proceedings·Chaitanya A SarawateAlan W Bakst
Mar 14, 2007·Arthritis Research & Therapy·Alexander SoJürg Tschopp
Aug 31, 2007·Annals of the Rheumatic Diseases·D H SolomonM A Brookhart
Sep 11, 2007·Advanced Drug Delivery Reviews·Merry R ShermanFernando Perez-Ruiz
Oct 9, 2007·Journal of the American Academy of Dermatology·Sima HalevyUNKNOWN EuroSCAR Study Group
Jan 15, 2008·Pharmacogenetics and Genomics·Christine LonjouUNKNOWN RegiSCAR study group
Jan 16, 2008·Clinical Pharmacokinetics·Sophie L StockerRichard O Day
Jul 17, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·C-C ChiouW-H Chung
Aug 30, 2008·The American Journal of Gastroenterology·Alberto PilottoUNKNOWN SOFIA Project Investigators
Nov 1, 2008·Seminars in Arthritis and Rheumatism·Robert A Terkeltaub
Jan 7, 2009·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Rachel HalpernTed R Mikuls
Mar 17, 2009·The Journal of Rheumatology·Michael A BeckerChristopher Lademacher
Mar 31, 2009·Arthritis Research & Therapy·Leslie R HarroldIra S Ockene
May 8, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Annie Pierre Jonville-BéraElisabeth Autret-Leca
Jun 6, 2009·The New England Journal of Medicine·Helen J LachmannUNKNOWN Canakinumab in CAPS Study Group
Sep 8, 2009·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Ingrid HuttonNicola Dalbeth
Apr 1, 2010·Drug Testing and Analysis·Vivekanand P KamathPhilip E Morris

❮ Previous
Next ❯

Citations

Mar 20, 2012·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Nataly MartiniAmanda Tieu
Aug 8, 2012·Therapeutic Advances in Musculoskeletal Disease·Ignacio Garcia-ValladaresLuis R Espinoza
Apr 5, 2013·Pharmacotherapy·Tran H TranVibhuti Arya
Jul 19, 2011·Clinical and Experimental Immunology·P Menu, J E Vince
Nov 26, 2010·Journal of the American Academy of Nurse Practitioners·Michael E ZychowiczElke Graser
Jan 4, 2017·The Journal of Dermatological Treatment·Daren A FominJonathan Crane
May 7, 2020·Asian Journal of Pharmaceutical Sciences·Bojana RisticVadivel Ganapathy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Arthritis Research & Therapy
Jasvinder A Singh
Arthritis Research & Therapy
Nathalie Busso, Alexander So
Current Opinion in Rheumatology
Hang-Korng Ea, Frédéric Lioté
© 2021 Meta ULC. All rights reserved