PMID: 19127859Jan 9, 2009Paper

Progress in the studies on small molecule IGF-1R inhibitors

Yao xue xue bao = Acta pharmaceutica Sinica
Yan XuLi-bao Xu

Abstract

The importance of insulin-like growth factor 1 receptor (IGF-1R) signaling in malignant behaviour of tumour cells is well established. Inhibiting the activity of IGF-1R may result in striking apoptosis in malignant cells growing. IGF-1R antibodies which are currently in phase I and II clinical trials and several IGF-IR TKIs have preclinically been characterized. This review describes recent developments of small molecule tyrosine kinase inhibitors.

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