PMID: 11897968Mar 19, 2002Paper

Progress of capillary electrophoresis in therapeutic drug monitoring and clinical and forensic toxicology

Therapeutic Drug Monitoring
W Thormann

Abstract

During the past decade, capillary electrophoresis (CE) emerged as a promising, effective, and economical approach for the analysis of licit and illicit drugs and their metabolites in biologic samples. This review provides an overview of the principles of CE, the features of CE instrumentation, and the key aspects of CE-based drug assays that were developed for therapeutic drug monitoring (TDM), clinical and forensic toxicology, and assessment of drug metabolism and pharmacokinetics. CE performed in fused-silica capillaries has sufficiently matured and can thus be applied routinely, whereas chip-based instrumentation comprising fully integrated assays is still in development. Despite the attractive advantages of electrokinetic capillary technology, relatively few CE-based assays for TDM and for drug screening of clinical and forensic interest have been adopted in the routine arena. The lack of complete systems designed for unattended operation, the reluctance of bioanalysts to replace a satisfactory existing method, and tight budgets are believed to have hindered the widespread replacement of older (mainly chromatographic) technology. Another limitation of CE is that this technique is somewhat less sensitive than other analytic ...Continue Reading

References

Mar 18, 1994·Journal of Chromatography. B, Biomedical Applications·J M DethyP Gilbert
Jan 1, 1994·Electrophoresis·W ThormannA Schmutz
Aug 1, 1996·Therapeutic Drug Monitoring·W ThormannA Schmutz
Aug 9, 1996·Journal of Chromatography. B, Biomedical Applications·Z K Shihabi, K S Oles
Jun 6, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·M FrostG Blaschke
Oct 29, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·R LehmannH M Liebich
Feb 12, 1998·Electrophoresis·C L ColyerD J Harrison
Feb 10, 1998·Electrophoresis·F von Heeren, W Thormann
Jun 17, 1998·Forensic Science International : Synergy·W ThormannJ Caslavska
Jul 1, 1998·Journal of Chromatography. a·Z K Shihabi
Aug 13, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·F TagliaroM Marigo
Nov 21, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·J G MöllerG Blaschke
Dec 31, 1998·Electrophoresis·W Thormann, J Caslavska
Dec 31, 1998·Electrophoresis·L J Brunner, J T DiPiro
Oct 20, 1999·Journal of Chromatography. a·K D Altria
Dec 22, 1999·Electrophoresis·S H Chen, Y H Chen
Feb 25, 2000·Therapeutic Drug Monitoring·G ManettoF Tagliaro
Jun 6, 2000·Journal of Chromatography. a·S Zaugg, W Thormann
Sep 21, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·K Govindaraju, D K Lloyd

❮ Previous
Next ❯

Citations

Jun 19, 2007·Analytical and Bioanalytical Chemistry·Franco TagliaroJennifer P Pascali
Jun 21, 2007·Journal of Analytical Toxicology·Michael L SmithMarilyn A Huestis
Jul 26, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Carolien M Boone, Kees Ensing
Mar 2, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Elena Llorente FernándezJordi To-Figueras
Jun 15, 2010·Journal of Pharmaceutical and Biomedical Analysis·Regula TheurillatWolfgang Thormann
May 11, 2005·Journal of Separation Science·Juan José Berzas NevadoFrancisco Javier Guzmán Bernardo
Apr 12, 2007·Electrophoresis·Maike SniehottaHarald Mischak
Jul 17, 2013·Journal of Separation Science·Regula TheurillatWolfgang Thormann
Mar 28, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Andres Herane-VivesAllan H Young

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.