Progress of Exosomes in the Diagnosis and Treatment of Pancreatic Cancer

Genetic Testing and Molecular Biomarkers
Hongpei WuMingbing Xiao

Abstract

Pancreatic cancer (PC) is a digestive system tumor that is highly malignant, with an increasing incidence rate, poor prognosis, and a low 5-year survival rate. The overwhelming majority of patients with PC are in an advanced stage at the time of diagnosis and have lost the opportunity for radical surgery. The efficacy of radiotherapy and chemotherapy for PC is very poor. Therefore, it is of great significance to explore the mechanisms of PC development and new therapeutic targets. Exosomes are extracellular vesicles that mediate the exchange of substances and information between cells. In recent years, exosomes have been shown to play a key role in the development and progression of PC and might be useful for both its diagnosis and treatment. This article reviews the composition and function of exosomes and their roles in the development, diagnosis, and treatment of PC.

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Citations

Aug 8, 2019·Cancer Medicine·Xinqi JiaShan Yu
Feb 10, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Constança OliveiraMaria Teresa Cruz
Nov 1, 2020·Drug Discovery Today·Batoul Farran, Ganji Purnachandra Nagaraju
Jul 1, 2021·Cancer Management and Research·Xi WangHaijun Zhang

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