Progress of experimental study on treatment of psoriasis by Chinese medicinal monomer and single or compound recipe in Chinese materia medica

Chinese Journal of Integrative Medicine
Hong Zhang, Jun Gu

Abstract

Psoriasis is a common, chronic, recurrent inflammatory skin disorder whose etiology is still unknown. It is believed that a multiple-gene inheritance is involved and it also involves various factors such as immunity, inflammation, cell proliferation, apoptosis, neural media, etc. Since cytokines are key mediators in inflammation, a number of Chinese medicines (CMs) have been reported to have certain antagonist effects on pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), platelet active factor (PAF) and interleukin-8 (IL-8). Some researches on CMs have made significant breakthroughs in psoriasis by intervening with cytokines. Abnormalities with keratinocyte proliferation and apoptosis are considered to be present in patients with psoriasis and a number of studies show that the mechanism of CMs on psoriasis may be through the inhibition of the keratinocyte proliferation and induction of apoptosis. Other studies also show that the inhibition of fibroblast-secreted cytokines could regulate keratinocyte proliferation and differentiation and reduce the level of Calcitonin gene-related peptide (CGRP) in plasma and in lesions so as to slow down the process of inflammation and proliferation in psoriasis. The mo...Continue Reading

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Citations

Apr 3, 2012·Chinese Journal of Integrative Medicine·Brian H MayCharlie C L Xue
May 22, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Chong-Fai MokChristopher Hon-Ki Cheng
Sep 16, 2016·The Journal of Dermatological Treatment·Yu XiangKaiyi Wang
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Jan 31, 2009·Chemistry & Biodiversity·Zhen-Yu LiYue-Wei Guo
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Jul 3, 2019·Chemistry & Biodiversity·Jin-Hai YuHua Zhang
Jan 28, 2018·Journal of the American Heart Association·Yuan LuHarlan M Krumholz

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