PMID: 29071919Jun 25, 2016Paper

Progress of Researches on Protective Effect of Acupuncture and Moxibustion in Relieving Intracellular Calcium Overload of Cradiomyocytes

Zhen ci yan jiu = Acupuncture research
Yan XiaoHao Chen

Abstract

Myocardial contraction and relaxation are regulated by increases and decreases of the intracellular cytoplasmic calcium (Ca2+) concentration. Intracellular calcium ion is also a ubiquitous second messenger, and its related signal transduction pathways involve a variety of physiological activities and pathological changes. It has been well documented that intracellular calcium overload is involved in myocardial cellular injury. In the present paper, the authors make a review about experimental researches on the underlying mechanisms of acupuncture and moxibustion in the prevention and treatment of ischemic myocardial injury from reducing calcium overload in recent 10 years. Results of recent studies indicate that acupuncture and moxibustion interventions have a cardioprotective effect by raising Ca2+-ATPase activity and nitric oxide content, lowering L-type voltage depen-dent calcium channel activity, and ameliorating calcium overload in ischemic cardiomyocytes mainly through cytomembrane, sarcoplasmic reticulum membrane and mitochondrial membrane pathways. However, the current studies on the mechanisms of acupuncture in the improvement of the ischemic myocardial injury are far unclear up to now and do not closely combine the cl...Continue Reading

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