PMID: 15228674Jul 2, 2004Paper

Progress of studies on enhancing efficiency of gene transfection into hematopoietic cells with the adenoviral vector--review

Zhongguo shi yan xue ye xue za zhi
Li-Sha WangLi-Sheng Wang

Abstract

Recombinant adenoviral vectors have been widely applied for the basic research and clinical trials of gene therapy. However, the inability of adenovirus to infect hematopoietic cells which lack the specific adenovirus receptors-coxsackie virus and adenovirus receptor (CAR) represents an important limitation in therapeutic applications. This limitation may be overcome by several approaches including modification of adenovirus vector and improvement of the susceptibility of hematopoietic cells. The current progresses in this field were summarized.

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
Ahmad F Haeri MazanderaniTheunis Avenant
© 2022 Meta ULC. All rights reserved