Progress on the road to new nerve agent treatments

Journal of Applied Toxicology : JAT
C A Broomfield, S D Kirby

Abstract

In the 50 years since nerve agents were developed a great deal has been learned about their acute toxicity, treatment and prophylactic strategies. However, the currently fielded treatments are not significantly different from those available at the end of World War II. Reasons for this lack of progress and strategies to circumvent those intrinsic problems that have impeded progress are discussed, with emphasis on the development of scavengers to be introduced as prophylactics that will significantly reduce the effective dose and thus protect against multiple times the normal LD50.

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Citations

Aug 1, 2007·Applied Microbiology and Biotechnology·David A SchofieldAugustine A DiNovo
May 26, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Laxmikant S DeshpandeRobert J DeLorenzo
May 16, 2014·Biochemical and Biophysical Research Communications·Young-Su JeongHak-Sung Kim
Aug 30, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Stan RyniakJoanna Hałas
Jul 1, 2008·Chemico-biological Interactions·Brian R ColemanMadhusoodana P Nambiar
Apr 22, 2003·Annual Review of Biomedical Engineering·Alan J RussellRichard R Koepsel
Jun 22, 2016·Annals of the New York Academy of Sciences·Laxmikant S DeshpandeRobert J DeLorenzo
Apr 8, 2003·Nature Structural Biology·Sompop BencharitMatthew R Redinbo
Jul 8, 2020·International Journal of Environmental Research and Public Health·Jackie ZhuLaxmikant S Deshpande

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