Progress report: familial pancreatic cancer

Familial Cancer
Ioannis Mintziras, Detlef K Bartsch

Abstract

A hereditary predisposition to pancreatic ductal adenocarcinoma (PDAC) is reported in approximately 5% of patients. Familial pancreatic cancer (FPC) accounts for the vast majority of hereditary PDAC cases. FPC defines families with two or more affected first-degree relatives with PDAC that do not fulfil the criteria of any other inherited tumor syndrome or families with PDAC in three or more relatives of any degree. The current progress report focuses on the knowledge of FPC with regard to molecular pathogenesis, clinical and molecular diagnosis, surveillance and novel treatment options reported in the last 5 years.

References

Jan 14, 2010·Journal of the National Cancer Institute·Kieran A BruneAlison P Klein
Mar 3, 2010·Familial Cancer·Emily P SlaterDetlef K Bartsch
Jun 6, 2012·Nature Reviews. Gastroenterology & Hepatology·Detlef K BartschPeter Langer
Nov 9, 2012·Gut·Marcia Irene CantoUNKNOWN International Cancer of Pancreas Screening (CAPS) Consortium
Nov 23, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas P PotjerUNKNOWN FaPaCa registry
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Nov 5, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bella KaufmanSusan M Domchek
May 20, 2015·Gut·F HarinckUNKNOWN Dutch research group on pancreatic cancer surveillance in high-risk individuals
Jul 2, 2015·Cancer Chemotherapy and Pharmacology·David FogelmanLuis A Diaz
Dec 15, 2015·Cancer Discovery·Nicholas J RobertsAlison P Klein
Apr 27, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans VasenDetlef K Bartsch
May 26, 2016·Gut·D K BartschT M Gress
Aug 5, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Marcin R LenerJan Lubiński
Oct 13, 2016·Oncotarget·Erina TakaiToru Furukawa
Jul 9, 2017·Familial Cancer·Thomas P SlavinUNKNOWN Clinical Cancer Genomics Community Research Network (CCGCRN)
Jul 21, 2017·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Kari G ChaffeeGloria M Petersen
Oct 28, 2017·Gastroenterology·Robert C GrantSteven Gallinger
Jan 6, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Masaya SuenagaMichael Goggins
May 19, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Juan E CorralMichael B Wallace

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Citations

Dec 24, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Marta PuzzonoGiulia Martina Cavestro

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Methods Mentioned

BETA
exome sequencing
pancreatectomy

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