Progress report of a randomized trial comparing long-term survival and late toxicity of concurrent chemoradiotherapy with adjuvant chemotherapy versus radiotherapy alone in patients with stage III to IVB nasopharyngeal carcinoma from endemic regions of China

Cancer
Yong ChenJun Ma

Abstract

The objective of this study was to evaluate the long-term survival and late toxicities of concurrent-adjuvant chemotherapy in patients with stage III through IVB nasopharyngeal carcinoma (NPC) from endemic regions of China. Patients with stage III to IVB NPC were assigned randomly to receive radiotherapy (RT) alone (the RT group) or RT plus concurrent adjuvant chemotherapy (the CRT group). CRT patients received concurrent cisplatin (40 mg/m2) weekly during RT followed by cisplatin (80 mg/m2) and fluorouracil (800 mg/m(2) daily for 5 days) every 4 weeks for 3 cycles. The primary endpoint was overall survival. In total, 316 patients underwent randomization, with 158 to each group. At a median follow-up of 70 months, the 5-year overall survival rate was 72% for the CRT group and 62% for the RT group (hazard ratio, 0.69; 95% confidence interval, 0.48-0.99; P = .043). Failure-free survival was significantly higher in the CRT group (P = .020). Most late toxicities were similar (33% vs. 26%; P = .089), except for cranial neuropathy (P = .042), peripheral neuropathy (P = .041), and ear damage (P = .048), which were significantly increased in the CRT group. The addition of concurrent adjuvant chemotherapy to RT provides survival benefit...Continue Reading

References

May 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R W GreggD J Stewart
Jan 1, 1981·Cancer·A B MillerA Winkler
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Al-SarrafJ F Ensley
Aug 3, 2001·International Journal of Radiation Oncology, Biology, Physics·J MaH Q Min
Apr 17, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A T C ChanP J Johnson
May 23, 2002·International Journal of Radiation Oncology, Biology, Physics·Daniel T T ChuaDamon Choy
Feb 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jin-Ching LinWen-Yi Wang
Nov 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A LangendijkB J Slotman
Jan 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel T T ChuaHua-Qing Min
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne W M LeeUNKNOWN Hong Kong Nasopharyngeal Cancer Study Group
Oct 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Li ZhangShao-Xiong Wu
Dec 27, 2005·International Journal of Radiation Oncology, Biology, Physics·Bertrand BaujatUNKNOWN MAC-NPC Collaborative Group
Oct 17, 2008·International Journal of Radiation Oncology, Biology, Physics·S H ChanS K Chow

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Citations

Jul 15, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Zhong-Guo LiangXiao-Dong Zhu
Aug 6, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yu-Pei ChenJun Ma
Sep 1, 2015·Lancet·Melvin L K ChuaAnthony T C Chan
May 11, 2015·The Lancet Oncology·Pierre BlanchardUNKNOWN MAC-NPC Collaborative Group
Jul 19, 2015·Current Treatment Options in Oncology·Wai Tong NgAnne W M Lee
Jun 6, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Marie YanKelvin K W Chan
May 6, 2015·Oncoimmunology·Norma BloyLorenzo Galluzzi
Nov 17, 2015·Hematology/oncology Clinics of North America·Henry SzeAnne W M Lee
Nov 26, 2016·International Journal of Molecular Sciences·Xin WenNa Liu
Dec 9, 2016·Journal of the National Cancer Institute·Federico RotoloUNKNOWN MAC-NPC Collaborative Group
Oct 13, 2018·Journal of Oncology Practice·Victor H LeeAnne W Lee
Jul 6, 2019·The Journal of International Medical Research·Chun WangJun Yan
Mar 20, 2020·American Society of Clinical Oncology Educational Book·Brigette B Y MaJun Ma
Mar 17, 2020·Current Opinion in Oncology·Edwin Pun HuiAnthony T C Chan
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne W M LeeAnthony T C Chan

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