Progress report on new antiepileptic drugs: A summary of the Twelfth Eilat Conference (EILAT XII)

Epilepsy Research
M BialerH Steve White

Abstract

The Twelfth Eilat Conference on New Antiepileptic Drugs (AEDs) - EILAT XII, took place in Madrid, Spain from August 31st to September 3rd 2014. About 130 basic scientists, clinical pharmacologists and neurologists from 22 countries attended the conference, whose main themes included "Conquering pharmacoresistant epilepsy", "Innovative emergency treatments", "Progress report on second-generation treatment" and "New methods and formulations". Consistent with previous formats of this conference, a large part of the program was devoted to a review of AEDs in development, as well as updates on AEDs introduced since 2004. Like the EILAT X and EILAT XI reports, the current article focuses on the preclinical and clinical pharmacology of AEDs that are currently in development. These include adenosine-releasing silk, allopregnanolone (SAGE-547), AMP-X-0079, brivaracetam, bumetanide, cannabidiol, cannabidivarin, 2-deoxy-glucose, everolimus, ganaxolone, huperzine A, imepitoin, minocycline, NAX 801-2, pitolisant, PRX 0023, SAGE-217, valnoctamide and its homologue sec-butyl-propylacetamide (SPD), and VLB-01. Since the previous Eilat conference, perampanel has been introduced into the market and twelve novel potential epilepsy treatments are ...Continue Reading

References

Oct 1, 1992·Pain·A TjølsenK Hole
Aug 11, 1990·Acta Physiologica Scandinavica·S LindskogB Ahrén
Mar 1, 1987·Acta Physiologica Scandinavica·S Lindskog, B Ahrén
Aug 1, 1981·Journal of Clinical Pharmacology·E A Carlini, J M Cunha
Nov 1, 1982·Journal of Clinical Pharmacology·T TurmenJ V Aranda
Nov 1, 1981·Journal of Clinical Pharmacology·I H Tuzel
Oct 1, 1995·Neurology·E FavaleC Albano
Mar 1, 1995·Epilepsia·T KivirantaE M Airaksinen
Jan 1, 1997·Biology of the Neonate·A M Lopez-SamblasM W Modi
Nov 24, 1998·Journal of Clinical Pharmacology·J D MarshallG L Kearns
Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·S LuisiA R Genazzani
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·A M MalfaitM Feldmann
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Külliki SaarUlo Langel
Aug 21, 2003·Drug Discovery Today·Gerhard Müller
Nov 13, 2003·Progress in Neurobiology·Jeremy J LambertJohn A Peters
Jan 23, 2004·Journal of Medicinal Chemistry·Benoit M KendaPhilippe Michel
Jan 30, 2004·Clinical Pharmacokinetics·Gabriele I KirchnerMichael P Manns
Feb 6, 2004·British Journal of Pharmacology·Lisa Walter, Nephi Stella
Feb 27, 2004·Brain : a Journal of Neurology·Isabelle MerletFrançois Mauguière
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Berkley A LynchBruno Fuks
Aug 12, 2004·Neurology·UNKNOWN Huntington Study Group
Aug 24, 2004·Combinatorial Chemistry & High Throughput Screening·R W DeSimoneD A Pippin
Apr 19, 2005·Expert Opinion on Investigational Drugs·Janet E Dancey
Jun 17, 2005·Nature Reviews. Neuroscience·Delia Belelli, Jeremy J Lambert
Aug 25, 2005·Medicine and Science in Sports and Exercise·Antonio Pelliccia, Fernando M Dipaolo
Sep 24, 2005·Psychopharmacology·Erika TimbyInger Sundström Poromaa
Oct 18, 2005·Nature Medicine·Volodymyr I DzhalaKevin J Staley
Dec 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Delia BelelliJeremy J Lambert

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Citations

Jan 14, 2016·Expert Opinion on Pharmacotherapy·Pavel KleinIvan Rektor
Nov 5, 2015·Expert Opinion on Investigational Drugs·Marco Mula
Dec 23, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gaetano Zaccara, Dieter Schmidt
Aug 21, 2015·Bipolar Disorders·Bogdan J WlodarczykRichard H Finnell
Jun 16, 2015·Epilepsy & Behavior : E&B·Nikolaus J Sucher, Maria C Carles
Mar 1, 2016·Expert Opinion on Drug Discovery·Krzysztof ŁukawskiStanisław J Czuczwar
Mar 16, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Antonio LeoMaurizio Elia
Aug 25, 2015·Current Neurology and Neuroscience Reports·Ahmad BayrleeGretchen M Brophy
Dec 3, 2014·European Journal of Pharmacology·Kathrin TöllnerWolfgang Löscher
Mar 24, 2016·BioMed Research International·Osvaldo Garrido-AcostaGermán Chamorro-Cevallos
Apr 19, 2016·Expert Review of Neurotherapeutics·U DamarA Rotenberg
Jun 16, 2016·Drug and Alcohol Dependence·Zhiqiang Meng, James K Rowlett
Oct 22, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mariana MatiasGilberto Alves
Sep 23, 2016·Virology·Sara OrnaghiAnthony N van den Pol
Sep 21, 2016·Metabolic Brain Disease·Iwona ZarnowskaMaciej Gasior
Nov 2, 2016·Frontiers in Pharmacology·Jennifer C WongAndrew Escayg
Nov 12, 2016·Experimental Neurology·Ryan S SprisslerMichael F Hammer
Jul 25, 2017·Expert Opinion on Pharmacotherapy·Jasmina R MilovanovićMarina Kostić
Aug 26, 2017·Toxins·Lívea Dornela GodoyWagner Ferreira Dos Santos
Dec 8, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·V A KarlovI G Rudakova
Aug 6, 2017·Annals of Neurology·Eric S RosenthalStephen J Kanes
Sep 27, 2018·Expert Opinion on Emerging Drugs·Marco Mula
Dec 12, 2017·Epilepsy Currents·Dipan C PatelCameron S Metcalf
Jan 19, 2018·Journal of Epilepsy Research·Emilio Perucca
Nov 17, 2017·The Journal of Pharmacology and Experimental Therapeutics·Shu-Hui Chuang, Doodipala Samba Reddy

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