PMID: 41697Jan 1, 1979

Progress toward a voluntary oral consumption model of alcoholism

Drug and Alcohol Dependence
T K LiM B Waller

Abstract

With the goal of obtaining a suitable animal model for voluntary oral consumption of ethanol, the investigators selectively bred lines of alcohol-preferring and alcohol-nonpreferring rats, with preference considered as a function of the concentration of ethanol ingested. Studies with these animals showed that drinking is voluntary and not contingent on caloric restriction; that they will work to obtain ethanol even when food and water are freely available, and in so doing, show psychological or behavioral tolerance; that the amount of ethanol voluntarily consumed approaches their apparent maximum capacity for ethanol elimination. This amount of ethanol was capable of altering brain neurotransmitter content, thus exerting a CNS pharmocologic effect. In addition, the rats will bar-press for intravenous administration of ethanol, and with prolonged, free-choice consumption, ethanol intake increases to as much as 12 g per kg body weight per day without producing behavioral deficits, suggesting the development of tolerance.

References

Mar 1, 1993·Behavior Genetics·T K LiD P Doolittle
Jan 1, 1988·Journal of Neural Transmission·D T WongT K Li
Jun 3, 1996·European Journal of Pharmacology·R SpanagelW Zieglgänsberger
Dec 1, 1993·Physiology & Behavior·A Bisaga, W Kostowski
Jan 1, 1982·Pharmacology, Biochemistry, and Behavior·J M MurphyT K Li
Oct 1, 1982·Pharmacology, Biochemistry, and Behavior·M B WallerT K Li
Mar 1, 1982·Pharmacology, Biochemistry, and Behavior·M B WallerT K Li
Oct 1, 1983·Pharmacology, Biochemistry, and Behavior·M B WallerT K Li
May 1, 1986·Pharmacology, Biochemistry, and Behavior·G I ElmerF R George
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·M C RitzR A Meisch
Sep 1, 1987·Pharmacology, Biochemistry, and Behavior·G J GattoT K Li
Jun 1, 1987·Pharmacology, Biochemistry, and Behavior·F R George
Sep 1, 1992·Pharmacology, Biochemistry, and Behavior·A H RezvaniC J Gordon
Apr 1, 1993·Pharmacology, Biochemistry, and Behavior·B A Gosnell, D D Krahn
Aug 1, 1996·Pharmacology, Biochemistry, and Behavior·R A NadalN S Ferré
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·S W Kiefer
Jan 1, 1988·Pharmacology & Therapeutics·L A Pohorecky, J Brick
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·A H Rezvani, D S Janowsky
May 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·F R George
May 1, 1992·Alcohol·B A Gosnell, D D Krahn

Citations

Apr 1, 1978·Pharmacology, Biochemistry, and Behavior·P E PennT K Li
Sep 15, 1975·Life Sciences·H AltshulerP Phillips
Apr 1, 1975·Acta Physiologica Scandinavica·L Ahtee, K Eriksson
Jul 1, 1975·Pharmacology, Biochemistry, and Behavior·B E HunterD W Walker
May 25, 1972·Annals of the New York Academy of Sciences·G E McClearn
Apr 30, 1973·Annals of the New York Academy of Sciences·L Ahtee, K Eriksson
Feb 1, 1973·Archives of General Psychiatry·D W GoodwinG Winokur
Jun 7, 1974·Nature·J D Sinclair
Feb 1, 1971·Physiology & Behavior·T J CiceroL W Swanson
Dec 23, 1966·Science·R KakihanaI R Tabershaw
Dec 1, 1964·Journal of Neurochemistry·R TAKAHASHI, M H APRISON

Related Concepts

Ethanol
Behavior, Animal
Exertion
Ethanol Measurement
Neurosteroids
Drug Tolerance
Brain
Withdrawal Symptoms
Weighing Patient
Alcohol Abuse

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.