Progress Toward Development of Effective and Safe African Swine Fever Virus Vaccines

Frontiers in Veterinary Science
Huldah SangWaithaka Mwangi

Abstract

African swine fever is a major concern due to its negative impact on pork production in affected regions. Due to lack of treatment and a safe vaccine, it has been extremely difficult to control this devastating disease. The mechanisms of virus entry, replication within the host cells, immune evasion mechanisms, correlates of protection, and antigens that are effective at inducing host immune response, are now gradually being identified. This information is required for rational design of novel disease control strategies. Pigs which recover from infection with less virulent ASFV isolates can be protected from challenge with related virulent isolates. This strongly indicates that an effective vaccine against ASFV could be developed. Nonetheless, it is clear that effective immunity depends on both antibody and cellular immune responses. This review paper summarizes the key studies that have evaluated three major approaches for development of African Swine Fever virus vaccines. Recent immunization strategies have involved development and in vivo evaluation of live attenuated virus, and recombinant protein- and DNA-based and virus-vectored subunit vaccine candidates. The limitations of challenge models for evaluating ASFV vaccine ca...Continue Reading

References

Jan 1, 1988·Advances in Virus Research·C A Mebus
Aug 16, 2005·The Journal of General Virology·C A L OuraR M E Parkhouse
Jan 10, 2012·Transboundary and Emerging Diseases·J M Sánchez-VizcaínoB Martínez-López
Apr 4, 2012·Emerging Infectious Diseases·Sandra BlomeMartin Beer
Oct 9, 2012·Virus Research·Patricia de LeónAngel L Carrascosa
Nov 13, 2012·Virus Research·Mary-Louise PenrithArmanda D S Bastos
Nov 13, 2012·Virus Research·Linda K DixonChris Upton
Nov 21, 2012·Virus Research·Sílvia CorreiaRobert Michael Parkhouse
Dec 4, 2012·Virus Research·Haru-Hisa TakamatsuFernando Rodríguez
Feb 23, 2013·Antiviral Research·Jordi M ArgilaguetFernando Rodríguez
Nov 20, 2014·The Journal of General Virology·Raquel PortugalGünther M Keil
Dec 3, 2014·Journal of Comparative Pathology·J M Sánchez-VizcaínoL Carrasco
Dec 20, 2014·The Journal of General Virology·A MalogolovkinD L Rock
Oct 23, 2016·Transboundary and Emerging Diseases·V R MongerW L A Loeffen
Sep 16, 2016·Clinical and Vaccine Immunology : CVI·Shehnaz LokhandwalaWaithaka Mwangi
Mar 1, 2017·Veterinary Immunology and Immunopathology·Jaime Lopera-MadridMangkey A Bounpheng

❮ Previous
Next ❯

Citations

Dec 1, 2020·Frontiers in Veterinary Science·Jean N HakizimanaGerald Misinzo
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Megan C Niederwerder
Jan 1, 2020·Uirusu·Yasuko OrbaKeita Matsuno
Jul 3, 2021·Viruses·Hanna Turlewicz-PodbielskaMałgorzata Pomorska-Mól
Aug 8, 2021·Animals : an Open Access Journal From MDPI·Elizabeth A ClemmonsJohn W Dutton
Aug 27, 2021·Veterinary Sciences·Georgia D BrellouEleni D Tzika

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.