Progress toward overcoming hypoxia-induced resistance to solid tumor therapy

Cancer Management and Research
Sergey V Karakashev, Mauricio J Reginato

Abstract

Hypoxic tumors are associated with poor clinical outcome for multiple types of human cancer. This may be due, in part, to hypoxic cancer cells being resistant to anticancer therapy, including radiation therapy, chemotherapy, and targeted therapy. Hypoxia inducible factor 1, a major regulator of cellular response to hypoxia, regulates the expression of genes that are involved in multiple aspects of cancer biology, including cell survival, proliferation, metabolism, invasion, and angiogenesis. Here, we review multiple pathways regulated by hypoxia/hypoxia inducible factor 1 in cancer cells and discuss the latest advancements in overcoming hypoxia-mediated tumor resistance.

Citations

Nov 9, 2016·Cancer Investigation·Hamed Manoochehri KhoshinaniRezvan Najafi
Mar 30, 2018·The Journal of Experimental Biology·Vered DomankevichImad Shams
Dec 24, 2019·Frontiers in Oncology·Sara Sofia Deville, Nils Cordes
Jan 28, 2021·Cancers·Ilias MylonisGeorge Simos
Dec 10, 2020·Cells·Dimas Carolina BelisarioChiara Riganti
Jun 15, 2021·Frontiers in Immunology·Khalil KhalafMariusz Kaczmarek
Jul 15, 2021·Pathology Oncology Research : POR·Anna SebestyénJózsef Tímár
Dec 10, 2018·ACS Biomaterials Science & Engineering·Ying WangBin Duan

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Methods Mentioned

BETA
xenograft
xenografts
nuclear translocation
ubiquitination

Clinical Trials Mentioned

NCT00540176
NCT01386632
NCT00512798
NCT00061932
NCT00028821
NCT00088374
NCT00773344
NCT00121264
NCT00544674
NCT00394628

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