Progress toward Treatment and Cure of Epidermolysis Bullosa: Summary of the DEBRA International Research Symposium EB2015

The Journal of Investigative Dermatology
Jouni UittoE Clare Robinson

Abstract

Epidermolysis bullosa (EB), a group of complex heritable blistering diseases, is the topic of triennial research meetings organized by DEBRA International, Vienna, Austria, the network of national EB patient advocacy organizations. The DEBRA 2015 Research Conference, held in May 2015, brought together investigators and clinicians from around the world working at the forefront of EB research. Discussing the state-of-the-art approaches from a wide range of disciplines, there was a palpable excitement at this conference brought about by the optimism about applying new sequencing techniques, genome editing, protein replacement, autologous and allogeneic stem cell therapy, innovations in cancer biology, revertant mosaicism, and induced pluripotent stem cell techniques, all of which are aimed at developing new therapies for EB. Many in the field who have participated in EB research for many years were especially enthusiastic and felt that, possibly for the first time, the field seems uniquely poised to bring these new tools to effectively tackle EB. Multiple complementary approaches are currently in motion toward improved quality of life and eventually a cure for patients suffering from EB, a currently intractable disease.

Associated Clinical Trials

References

Sep 18, 2004·The Journal of Investigative Dermatology·Jack L ArbiserM Peter Marinkovich
Apr 3, 2008·The Journal of Clinical Investigation·Anja FritschLeena Bruckner-Tuderman
Apr 4, 2008·The Journal of Investigative Dermatology·Tracy WongJohn A McGrath
Nov 20, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jennifer RemingtonMei Chen
Nov 26, 2008·Journal of the American Academy of Dermatology·Jo-David FineChirayath Suchindran
May 7, 2009·The British Journal of Dermatology·A GostynskiM F Jonkman
Apr 16, 2010·The Journal of Investigative Dermatology·Jouni UittoE Clare Robinson
May 14, 2010·The Journal of Investigative Dermatology·Leena Bruckner-TudermanJouni Uitto
Jul 31, 2010·Matrix Biology : Journal of the International Society for Matrix Biology·Seong Hyun KimJouni Uitto
Oct 19, 2011·Proceedings of the National Academy of Sciences of the United States of America·Nicholas J WangRaymond J Cho
Sep 13, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Kara KampsEric Michael Bratsolias Brown
Oct 23, 2012·Trends in Molecular Medicine·Laure BidouOlivier Namy
May 9, 2013·Orphanet Journal of Rare Diseases·Verena WallyJohann W Bauer
May 22, 2013·Journal of Dermatological Science·Catharina Sagita MoniagaKenji Kabashima
Aug 21, 2013·The Journal of Investigative Dermatology·Leena Bruckner-TudermanJouni Uitto
Oct 1, 2013·Journal of the American Academy of Dermatology·Supriya S VenugopalDedee F Murrell
Nov 2, 2013·Journal of the American Academy of Dermatology·Antoni GostyńskiMarcel F Jonkman
Dec 10, 2013·The Journal of Investigative Dermatology·Jakub TolarJohn E Wagner
Feb 4, 2014·The Journal of Clinical Investigation·Lilli WinterGerhard Wiche
Feb 11, 2014·The British Journal of Dermatology·J J L SnauwaertM A Morren
Mar 1, 2014·The Journal of Investigative Dermatology·Dimitra KiritsiAnna M G Pasmooij
May 16, 2014·The Journal of Investigative Dermatology·Qiaoli Li, Jouni Uitto
May 27, 2014·Cell Reports·Jean AlbrenguesCedric Gaggioli
Sep 25, 2014·Clinical and Experimental Dermatology·M A El DaroutiR M Abdel Hay
Oct 29, 2014·The Journal of Investigative Dermatology·Johanna HammersenHolm Schneider
Nov 5, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Blanca DuarteFernando Larcher
Nov 28, 2014·Science Translational Medicine·Vittorio SebastianoAnthony E Oro
Nov 28, 2014·Science Translational Medicine·Noriko Umegaki-AraoAngela M Christiano
Nov 28, 2014·Science Translational Medicine·Daniel WenzelJosef M Penninger
Jan 13, 2015·Nature Communications·Esther HosteFiona M Watt
Apr 2, 2015·The Journal of Investigative Dermatology·Jens BohnekampThomas M Magin
Apr 24, 2015·The Journal of Investigative Dermatology·Gabriela PetrofJohn A McGrath
Jul 22, 2015·EMBO Molecular Medicine·Alexander NyströmLeena Bruckner-Tuderman

❮ Previous
Next ❯

Citations

Aug 9, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Jouni UittoLeena Bruckner-Tuderman
Aug 29, 2016·Stem Cell Research & Therapy·Vitali AlexeevOlga Igoucheva
Sep 10, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Alexander NyströmTobias Kühl
Jan 28, 2017·Matrix Biology : Journal of the International Society for Matrix Biology·Liliana GuerraDaniele Castiglia
May 24, 2016·The Journal of Investigative Dermatology·Andrew P South, Jouni Uitto
Feb 24, 2018·Clinical and Experimental Dermatology·A H SaeidianA P South
Jun 27, 2018·British Journal of Nursing : BJN·Victoria LynneJulie M Murdoch
Aug 23, 2019·The British Journal of Dermatology·J Uitto
Jul 9, 2016·Current Opinion in Pediatrics·Heather I Cohn, Joyce M C Teng
Jan 5, 2020·Orphanet Journal of Rare Diseases·Anna L BrucknerDedee F Murrell
Nov 10, 2018·Orphanet Journal of Rare Diseases·Antonia ReimerHagen Ott
Nov 10, 2020·Indian Journal of Dermatology·Tanusree SarkarDwijendra Nath Gangopadhyay
Jul 11, 2021·Indian Journal of Dermatology, Venereology and Leprology·Sujay KhandpurD R Gunaabalaji
Dec 21, 2017·The Journal of Investigative Dermatology·Jouni Uitto
Feb 3, 2018·The Journal of Investigative Dermatology·Jouni UittoClare Robinson
Oct 12, 2021·Journal of the American Academy of Dermatology·Gregory Scott PhillipsSharon A Glick

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Software Mentioned

DEBRA

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

Trends in Molecular Medicine
Katsuto TamaiJouni Uitto
The Journal of Investigative Dermatology
Varee PoocheronRobert S Kirsner
American Journal of Clinical Dermatology
Chao-Kai HsuJohn A McGrath
Journal of the American Academy of Dermatology
Antoni GostyńskiMarcel F Jonkman
© 2022 Meta ULC. All rights reserved