Progress toward Understanding the Interactions between DNA Nanostructures and the Cell

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Yee Ting Elaine ChiuChung Hang Jonathan Choi

Abstract

Advances in DNA nanotechnology empower the programmable assembly of DNA building blocks (oligonucleotides and plasmids) into DNA nanostructures with precise architectural control. As DNA nanostructures are biocompatible and can naturally enter mammalian cells without the aid of transfection agents, they have found numerous biological or biomedical applications as delivery carriers of therapeutic and imaging cargoes into mammalian cells for at least a decade. Nevertheless, mechanistic studies on how DNA nanostructures interact with cells have remained limited and incomprehensive until 2-3 years ago. This Review presents the recent progress in elucidating the "cell-nano" interactions of DNA nanostructures, with an emphasis on three key classes of structures commonly utilized in intracellular applications: tile-based structures, origami-based structures, and nanoparticle-templated structures. Structural parameters of DNA nanostructures and strategies of biochemical modification for promoting intracellular delivery are discussed. Biological mechanisms for cellular uptake, including specific pathways and receptors involved, are outlined. Routes of intracellular trafficking and degradation, together with strategies for re-directing t...Continue Reading

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Citations

Aug 1, 2019·Chembiochem : a European Journal of Chemical Biology·Jiahui FanZhou Nie
Sep 13, 2019·Current Pharmaceutical Design·Dusica Maysinger, Jeff Ji
Jan 15, 2020·Advanced Biosystems·Qi ShenChenxiang Lin
May 30, 2020·Molecular Pharmaceutics·Mingyue CuiChenjie Xu
Jul 16, 2019·ACS Applied Materials & Interfaces·Zhong ChenChung Hang Jonathan Choi

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