Progress towards a coordinated, national paediatric antimicrobial resistance surveillance programme: Staphylococcus aureus, enterococcal and Gram-negative bacteraemia in Australia.

The Journal of Antimicrobial Chemotherapy
Anita J CampbellChristopher C Blyth

Abstract

There is increasing knowledge of antimicrobial usage in children yet limited availability of nationally representative paediatric-specific data on antimicrobial resistance. Paediatric data from this national surveillance programme are presented to explore differences between childhood and adult bloodstream infections and antimicrobial resistance surveillance. Using information collected from a prospective coordinated antimicrobial resistance surveillance programme, children ≤18 years and adults >18 years with a positive blood culture for Staphylococcus aureus, Enterococcus spp. or Gram-negative spp. presenting to one of 34 Australian hospitals during 2013-16 were evaluated. Consistent methodologies for key sepsis pathogens were employed and a comparative analysis between children and adults was conducted. There are stark contrasts between children and adults in this national antimicrobial resistance (AMR) data set. Notable differences include lower rates of AMR, different clinical and molecular phenotypes and lower mortality amongst children. The burden of Gram-negative resistance is disproportionately experienced in children, with higher odds of death with an ESBL versus non-ESBL bacteraemia in comparison with adults. These da...Continue Reading

References

Oct 10, 2012·BMC Infectious Diseases·Steven Y C TongUNKNOWN Australian New Zealand Cooperative on Outcomes in Staphylococcal Sepsis
Mar 19, 2014·Journal of Infection and Public Health·Caitlin M WolfeElaine Larson
Oct 7, 2018·World Journal of Pediatrics : WJP·Jim ButteryUNKNOWN World Society for Pediatric Infectious Diseases

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