PMID: 6163954Feb 1, 1981Paper

Progress towards a unified theory of the mechanisms of carcinogenesis: role of cell cycle restriction points

Medical Hypotheses
L A Hull

Abstract

Cancer is characterized by a relatively autonomous growth of cells due to a reduced responsiveness to normal controls of proliferation and differentiation. The proliferation of normal cells is regulated at arrest (restriction) points in the cell cycle. Relatively autonomous growth (tumors) can result from various mechanisms which circumvent the normal regulatory controls of the cell cycle.

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