PMID: 11322371Apr 27, 2001Paper

Progression after release of obstructive nephropathy

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
W ChanJ C Chan

Abstract

Progressive glomerular and tubulointerstitial fibrosis develop in 1-year-old rats even after relief (R) of unilateral ureteral obstruction (UUO) at 5 days of age. The present study investigated whether a progressive renal injury model of UUO could be achieved after reversal of UUO (RUUO) in adult instead of neonatal rats. The potential for alpha-tocopherol modulation of mRNA for the fibrogenic cytokine, transforming growth factor-beta1 (TGFbeta1), apoptosis (TUNEL assay), and the presence of the stress protein, heat shock protein-70 (HSP-70), was also studied in this post-obstructive model. Male Sprague-Dawley rats weighing 125-150 g were randomly assigned to groups of 4 animals each for durations of 7 or 14 days of alpha-tocopherol supplementation after RUUO. The groups included: (i) sham, regular chow; (ii) RUUO, regular chow; (iii) RUUO, contralateral nephrectomy (NX); and (iv) RUUO, NX plus alpha-tocopherol supplementation. We found a significant increase in the ratio of kidney weight/body weight in the RUUO+NX group at 14 days compared with the sham and RUUO groups. This rise in the RUUO+NX group was significantly reduced after 14 days of alpha-tocopherol administration. The elevated level of kidney TGFbeta1 mRNA in the RU...Continue Reading

Citations

Jan 14, 2010·Journal of Anesthesia·Bayazit DikmenCankon Germiyanoglu
Jun 20, 2008·Cell Stress & Chaperones·Walter Manucha, Patricia Vallés
Jun 6, 2003·Kidney International·Douglas M SilversteinRobert L Chevalier
Feb 5, 2002·Annual Review of Physiology·Steven C Borkan, Steven R Gullans
Jan 22, 2010·American Journal of Physiology. Renal Physiology·Tipu S PuriRichard J Quigg
Apr 12, 2013·Rehabilitation Research and Practice·Grant L Iverson, Michael S Koehle
Nov 30, 2013·Advances in Urology·Luciana Mazzei, Walter Manucha
Nov 30, 2013·BioMed Research International·Orawan WongmekiatKamthorn Thamprasert
Feb 14, 2017·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Valentina Pastore, Fabio Bartoli
Aug 26, 2004·American Journal of Physiology. Renal Physiology·Keiichi ItoDiane Felsen
Dec 13, 2005·American Journal of Physiology. Renal Physiology·Neil G DochertyR William G Watson
Jun 20, 2019·Renal Failure·Jie SongWei Zhu
Jul 10, 2013·Experimental and Therapeutic Medicine·Hong-Zhou MengXiao-Dong Jin
Apr 17, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Patricia VallésDaniel R Ciocca

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